October 20, 2016
A low-intensity MRI signal in the infrapatellar fat pad was associated with an increased risk of knee cartilage defects, according to study findings.
“The infrapatellar fat pad (IPFP), the local fat around the knee joint, may play an important role in the initiation and progression of knee [osteoarthritis] OA,” Weiyu Han, MD, PhD, at the Menzies Institute for Medical Research of the University of Tanzania, and colleagues wrote. “Biomechanically, it can promote efficient lubrication, reduce impact loading and absorb forces generated through the knee joint, which may be protective against OA. Biochemically, it can produce various proinflammatory cytokines and adipokines, which may be deleterious to the knee joint.”