Benzophenones have been named the American Contact Dermatitis Society’s Allergen of the Year for 2014 in an effort to raise awareness for allergy and photoallergy to ubiquitous agents, according to researchers.
Previous studies have demonstrated that systemic exposure to the agents led to wheal and flare reactions and syncope after widespread application, according to Erin M. Warshaw, MD, MS, of the Minneapolis Veterans Affairs Medical Center, and colleagues.
Erin M. Warshaw
“Benzophenones are a family of structurally related ultraviolet (UV) filters that protect against UVB and some UVA radiation,” Ashley R. Heurung, BS, of the department of dermatology at the University of Minnesota Medical School, told Healio.com. “These ultraviolet filters are commonly incorporated into both cosmetic and toiletry products designed to protect human skin, hair, and nails and commercial products to prevent degradation and loss of structural integrity.”
Ashley R. Heurung
Heurung said benzophenone-3 (oxybenzone) is the most commonly used UV filter in the United States and the most common sunscreen contact and photocontact allergen in North America.
“Benzophenone-3 has been shown to cross-react with the UV filter octocrylene and topical NSAIDs such as ketoprofen,” she said.
This review and the literature emphasizes the importance of inclusion of these allergens in routine screening series, such as the ACDS Core Screening Series, the researchers concluded. – Samantha Costa
Disclosure: The researchers report no relevant financial disclosures.