Asthma/Lower Airway Diseases

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Dupilumab shows promise for uncontrolled persistent asthma in phase 3 trial

September 12, 2017

Results from the phase 3 Liberty Asthma Quest trial demonstrated that the investigational drug, dupilumab, reduced severe exacerbations and improved lung function in patients with uncontrolled persistent asthma, according to a press release issued by Regeneron Pharmaceuticals and Sanofi.

“Approximately one million U.S. adults and adolescents live with uncontrolled, persistent asthma, and continue to experience serious asthma attacks, despite taking an intensive regimen of standard therapies,” George D. Yancopoulos, MD, PhD, president and chief scientific officer of Regeneron, said in the release. “Dupilumab has now demonstrated positive late-stage results in two serious allergic diseases — asthma and atopic dermatitis — with robust efficacy and an extensive safety database. These results continue to support our hypothesis that the [interleukin (IL)]-4/IL-13 pathway is a critical driver of allergic disease, and we remain committed to further investigating the IL-4/IL-13 pathway in other allergic diseases.”

In the Journals

Probiotics ineffective for preventing asthma, eczema in infants

August 29, 2017
The use of Lactobacillus rhamnosus GG, a probiotic, is unable to prevent asthma or eczema in children at 2 years of age when used in the first 6 months of life.
In the Journals

COPD, asthma cited as important contributors to disease burden worldwide

August 25, 2017
In 2015, chronic obstructive pulmonary disease contributed to 3.2 million deaths worldwide and asthma contributed to 0.4 million deaths. These statistics demonstrate…
Feature

Pediatric asthma over 3 decades: The plateau beyond the epidemic

Infectious Diseases in Children, August 2017
From 1980 to 1987, the death rate from asthma in the United States rose from 1.3 per 100,000 population to 1.7, according to the CDC. Although asthma mortality rates had…
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