Allergic Disease Mechanisms

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Skin patch for peanut allergy yields higher immunity in children

December 22, 2016

Children were able to overcome allergic response to peanuts by wearing a skin patch that administered epicutaneous immunotherapy in the form of peanut protein, according to clinical trial findings published in the Journal of Allergy and Clinical Immunology.

“To avoid potentially life-threatening allergic reactions, people with peanut allergy must be vigilant about the foods they eat and the environments they enter, which can be very stressful,” National Institute of Allergy and Infectious Diseases director Anthony S. Fauci, MD, said in a press release. “One goal of experimental approaches such as epicutaneous immunotherapy is to reduce this burden by training the immune system to tolerate enough peanut to protect against accidental ingestion or exposure.”

In the JournalsPerspective

Infants’ peanut consumption found safe for future growth, nutrition

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Quilizumab appears tolerable, reduces serum IgE levels

April 25, 2016
Patients in this study who received quilizumab had reduced serum immunoglobulin E levels and appeared to tolerate the humanized IgG1 monoclonal antibody well, according…
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Novel IRF2BP2 mutation linked to CVID–like immunodeficiency

April 15, 2016
Researchers identified a novel mutation in IRF2BP2 in a family with a history of common variable immunodeficiency disorder, which may be the cause of the disease…
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