Patients who underwent immediate implant-based breast reconstruction with FlexHD acellular dermal matrices were more likely to develop infection and other complications when compared with other acellular dermal matrices, including AlloDerm, according to study results.
In research presented at the joint meeting of the American Association of Plastic Surgeons and the Plastic Surgery Research Council, researchers compared complications from immediate breast reconstructions in 810 patients from 11 sites. There were 507 patients reconstructed with AlloDerm (LifeCell), 128 patients with FlexHD (Ethicon) and 175 patients with another type of material, including AlloMax (Bard Davol), SERI Scaffold (Allergan), Biodesign (Cook Medical), SurgiMend (TEI Biosciences) or Vicryl (Ethicon).
The researchers used hierarchical logistic regression models to analyze complications including hematoma, seroma, mastectomy flap necrosis, wound infection, wound dehiscence and reconstructive failure, accounting for demographic and clinical variables.
Patients who had immediate breast reconstruction using FlexHD were significantly more likely to experience an infection (OR = 2.79; 95% CI, 1.07-7.26), reconstructive failure (OR = 3.3; 95% CI, 1.4-7.56), or any complication (OR = 2.8; 95% CI, 1.63-4.8) when compared with patients in the AlloDerm cohort.
“Patients undergoing immediate implant-based breast reconstruction with FlexHD had significantly increased odds of developing infection, reconstructive failure and any other sort of complication compared to those with AlloDerm,” the researchers concluded. – by Bruce Thiel
Santosa KB, et al. Are all acellular dermal matrices (ADMs) created equal? Results from a multicenter prospective study. Presented at: Joint meeting of American Association of Plastic Surgeons and the Plastic Surgery Research Council; May 19-22, 2016; New York.
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