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Phosphodiesterase-5 inhibitors may ease symptoms of Raynaud’s syndrome

December 1, 2015

Recently presented data showed patients with Raynaud’s syndrome treated with phosphodiesterase-5 inhibitors had reduced frequency and duration of disease flares, which were also less painful following treatment.

Using the Cochrane Library, MEDLINE, EMBASE and ClinicalTrials.gov to identify randomized controlled trials, researchers examined data from 255 patients with Raynaud’s syndrome treated with either phosphodiesterase-5 inhibitors or placebo. Of these patients, 97% had the disease secondary to systemic sclerosis. The studies included four trials with tadalafil, two trials with sildenafil and one trial with vardenafil. Characteristics identified included frequency, duration and severity of attacks and pain, Patient Global Scale score, withdrawals and serious adverse events, which investigators analyzed with fixed effects models, standardized mean differences or pooled risk ratios.

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VIDEO: Obinutuzumab induces B-cell cytotoxicity in samples from patients with RA, SLE

November 30, 2015
SAN FRANCISCO — Venkat Reddy, MRPC, discusses in vitro research with obinutuzumab and samples from patients with rheumatoid arthritis and systemic lupus…
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Patients with PsA who are misaligned with their physicians may have worse outcomes

November 30, 2015
Misalignment in disease perception between patients with psoriatic arthritis and their treating rheumatologists may result in worse outcomes and higher disease activity…

Amgen submits application to FDA for adalimumab biosimilar

November 30, 2015
Amgen recently announced it has submitted a Biologics License Application with the FDA for a biosimilar candidate to Humira. The biosimilar, known as ABP 501, is…
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Micronutrient deficiency may be common among patients with systemic sclerosis

November 30, 2015
Patients with systemic sclerosis were likely to be deficient in micronutrients, including selenium, folic acid and prealbumin, according to data presented by researchers…
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The Patient with Hereditary Angioedema

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Hereditary angioedema is an autosomal dominant disease that can present with any combination of painless, nonpruritic…
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VIDEO: Mamaras highlights CreakyJoints' patient advocacy

November 27, 2015
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The Patient with ANCA-Associated Vasculitis

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ANCA-associated vasculitis is a small-vessel disease associated with significant systemic manifestations. This CME…
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