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Lesinurad combination therapy increased serum uric acid levels in patients with gout

November 20, 2014

The combined use of a selective uric acid reabsorption inhibitor with allopurinol significantly increased the number of patients with gout who met their serum uric acid levels compared with use of allopurinol alone, according to results of two studies presented at the American College of Rheumatology Annual Meeting in Boston.

“There has not been much development over the last 30 years in treatment options for the millions of patients who fail to reach target serum uric acid levels on current standard-of-care therapy, such as allopurinol alone,” Kenneth G. Saag, MD, lead study author and professor of medicine at the University of Alabama in Birmingham, Ala., said in a press release. “The results from this first-of-its-kind, large phase 3 trial demonstrate the potential of combination therapy with lesinurad to provide a future treatment option for gout patients on allopurinol where additional therapy is needed.”

NIH renews research grants on aging

November 20, 2014
The NIH has announced renewed funding of $23.4 million for 11 Edward R. Roybal Centers for Research on Applied Gerontology and the designation of two additional…
In the Journals

Study results show higher rates of dose escalation in certain TNFi agents

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Similar persistence and clinical disease activity were seen after treatment with adalimumab, etanercept and infliximab; however, rates of dose escalation were highest…
Industry News

HHS, NIH propose changes to make more clinical trial data available

November 19, 2014
The Department of Health and Human Services and the National Institutes of Health are releasing two proposals for public comment designed to increase the transparency of…

‘Big Data’ analyses successfully reveal important patient insights

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Researchers have successfully analyzed “Big Data,” in this case, enormous amounts of details from electronic health records, to gain accurate insights into…
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Fixed Versus Onflare Retreatment with Rituximab in RA Results from the Cererra Collaboration

This activity is co-sponsored by Albert Einstein College of Medicine of Yeshiva University and Vindico Medical Education

Cererra Collaboration is a collaboration between 12 European countries with the aim to describe the use of rituximab in…
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CME
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Transaminase Levels and Hepatic Events Observed During Tocilizumab Treatment: Pooled Analysis of Long-term Clinical Trial Safety Data in Patients with Rheumatoid Arthritis

This activity is co-sponsored by Albert Einstein College of Medicine of Yeshiva University and Vindico Medical Education

We look to Transaminase Levels of Hepatic Events associated with the use of Tocilizumab in the treatment of Rheumatoid…
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morganatic-roan