February 12, 2016
Patients with myositis who had positive anti-Jo-1 antibody status had higher serum levels of visfatin linked to higher clinical muscle involvement based on a VAS, according to recently published research.
Researchers studied a group of 38 patients with myositis, 27 with polymyositis (PM) and 11 with dermatomyositis (DM), who were regularly followed at the Institute of Rheumatology in Prague. Longitudinal blood samples were available from 16 patients, and immunohistochemistry was available from 10 patients taken at the time of muscle biopsy. Muscle tissue from five patients with myasthenia gravis were used as noninflammatory control samples and a control group of 35 healthy participants were matched for age and sex.