August 24, 2016
Metformin significantly improved BMI and weight outcomes among children and adolescents who experienced weight gain associated with atypical antipsychotic use for autism spectrum disorders.
“The atypical antipsychotic medications risperidone and aripiprazole are the only treatments approved by the FDA for use in autism spectrum disorder (ASD). Both medications improve irritability and agitation symptoms in children with ASD as young as 5 (risperidone) or 6 (aripiprazole) years. Unfortunately, these medications also cause weight gain, and greater cumulative exposure is also associated with increased diabetes risk,” Evdokia Anagnostou, MD, of Holland Bloorview Kids Rehabilitation Hospital, Toronto, and colleagues wrote. “Although weight gain may be reversible, stopping these medicines often leads to relapse of irritability and agitation.”