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CHOP investigating safety of PEG 3350 for constipation in children

January 27, 2015

The Children’s Hospital of Philadelphia is investigating the safety of polyethylene glycol 3550 for treatment of constipation in the pediatric population, according to a press release.

The FDA-funded study aims to determine if certain components of PEG 3350 that are present in over-the-counter medications commonly prescribed for constipation in children are absorbed into the bloodstream, and if so, whether it causes adverse effects, the release explained. According to the NIH website, these components include “low molecular weight (LMW) species that may be found in PEG 3350 products (e.g., ethylene and diethylene glycol) and … PEG 3350 metabolites.” Although chronic use of PEG 3350 and use in children younger than 17 years is not approved by the FDA, it is used as such in clinical practice, according to the website.

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