DENVER — Supplementation with vitamin D decreased the risk for recurrent acute otitis media infection in young children, according to data presented here at the 2013 Interscience Conference on Antimicrobial Agents and Chemotherapy.
“The supplementation with vitamin D increased serum levels, and this increase is significantly associated with a reduction in the total number of AOM episodes,” Susanna Esposito, MD, of the University of Milan, said during a press conference. “However, it was interesting because we observed that the positive effect is significant in the group of children with recurrent AOM and lowering the risk of uncomplicated episodes of AOM.”
The prospective, randomized study included 116 children with a history of recurrent AOM. Participants received either 1,000 IU vitamin D per day or placebo for 4 months.
Researchers found that, in the treatment group, the number of participants experiencing one or more AOM episode was lower compared with the placebo group (P=.03). Differences were found in the number of participants who developed uncomplicated AOM (P<.001); however, no differences were found with the number of participants experiencing one or more episode of spontaneous otorrhea. AOM occurrence was significantly reduced in participants whose serum vitamin D concentrations were at least 30 ng/mL.
“Of course, some more studies are needed in order to identify whether in healthy children you can reduce the risk of AOM generally, not the risk of recurrences, in relation to vitamin D serum levels,” Esposito said. “More studies are needed to see if we can increase the population that can have a benefit from receiving vitamin D supplementation.”
For more information:
Esposito S. Abstract G-1249. Presented at: ICAAC 2013; Sept. 9-13, 2013; Denver.
Disclosure: The researchers report no relevant financial disclosures.