S. aureus associated with abscess, cellulitis infections in neonates

Community-associated methicillin-resistant Staphylococcus aureus was the most likely cause of abscess and cellulitis infections, according to recent study findings published in The Pediatric Infectious Disease Journal.

S. aureus causes infections ranging from localized pustulosis to invasive cases in neonates and infants,” according to background information in the study. “The emergence of community-associated methicillin-resistant S. aureus has complicated the diagnosis and management of S. aureus infections in this age group.”

The study included 179 healthy infants aged 60 days or younger with positive cultures for S. aureus.

Researchers found that participants aged 30 days or younger were more likely to have CA-MRSA infections compared with participants aged 31 to 60 days (62% vs. 43%, respectively). The most common diagnoses were abscess/cellulitis (n=94) and pustulosis (n=40). Urosepsis (n=1), pneumonia (n=4), meningitis (n=3), osteomyelitis (n=1) and bacteremia without a focus (n=2) were among the diagnosed invasive infections.

“This is the largest study of CA-S. aureus infection in infants <60 days old,” researchers wrote. “We found an overall yearly decrease of S. aureus infections among healthy infants ≤60 days old at [Texas Children’s Hospital] during this 5-year study. The decrease in infections may be explained by a combination of changes in the overall prevalence of S. aureus infections and/or health care providers being more comfortable managing infants with S. aureus infections as outpatients.”

Disclosure: The study was funded in part by Pfizer.