Female pediatric patients who were exposed to tenofovir for more than 1 year had an increased risk for proximal tubular dysfunction, according to a poster presentation at the XIX International AIDS Conference.
Researchers from Emory University conducted a prospective cohort study to measure the risk for proximal tubular dysfunction (PTD) among children and adolescents with HIV receiving tenofovir (Viread, Gilead Sciences). The study included 110 patients receiving tenofovir and 68 children receiving a non-tenofovir regimen who were followed for 12 months. Most of the patients were black and the mean age of the patients was 15.7 years. At enrollment, 62% of the patients had undetectable viral loads and the mean CD4 count was 550 cells/mm3.
There were 15 cases of PTD in 13 patients. One of these patients had never received tenofovir, three received tenofovir for less than 1 year and 11 received tenofovir for 1 year or more. Gender and duration of tenofovir exposure were associated with PTD. Females who were exposed to tenofovir for more than 1 year had a slight increased risk for PTD (P=.0016).
Patients who received tenofovir for longer periods of time had lower levels of phosphorus and creatinine clearance. Measuring levels of beta-2 microglobulin did not serve as a marker for early detection of PTD.
For more information:
- Camacho-Gonzalez A. #MOPE66. Presented at: XIX International AIDS Conference; July 22-27, 2012; Washington, D.C.