Colonization with S. aureus declines with age as gram-negative pathogens increase

WASHINGTON — As an infant’s nasopharynx is colonized with gram-negative pathogens, the colonization with Staphylococcus aureus declines.

S. aureus colonization of infants begins early in life and declines quickly, according to Pedro Alvarez-Fernandez, MD, a research fellow in Pediatrics/Infectious Disease at the University of Texas Medical Branch, Galveston, Texas, who presented his study findings here during the Pediatric Academic Societies Annual Meeting.

 

Pedro Alvarez-Fernandez

Alavarez and colleagues studied the rate of S. aureus colonization at monthly intervals and during viral upper respiratory infection (URI) in the first 6 months of life. Methicillin-resistant S. aureus has lower ability to maintain prolonged colonization than methicillin-susceptible strains in the first 6 months of life. Colonization in this age group is not associated with the risk for invasive infection.

“We are trying to see if we can change the colonization rate of S. aureus, what will happen with other bacteria?” Alvarez told Infectious Diseases in Children. “If we can change something with staph colonization, maybe we will get fewer infants with otitis.”

The investigators also studied the association of S. aureus colonization with environmental and host factors, and interaction with other pathogenic nasopharyngeal bacteria.

For more information:

Alvarez-Fernandez P. #1533.452. Presented at: Pediatric Academic Societies Annual Meeting; May 4-7, 2013; Washington.

Disclosure: Alvarez reports no relevant financial disclosures.

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