The first issues of the “New England Journal of Medicine and Surgery, and the Collateral Branches of Science” were published in a letterpress in 1812 and featured a handful of articles. Now, medical articles are catered via e-TOCs, email, aheads of prints, PDFs, RSSs, Kindles, iPads, and soon Facebook, Twitter and Angry Birds. It would be very hard to actually dimension the impact of this tremendous access. The half life of new knowledge decreases dramatically as access to information becomes ubiquitous. From 1948 to the present, PubMed now provides instant access to 18 million journal citations. PubMed Central hosts 1.5 million full-text articles. And when you look at the trend over time, it points up like our fiscal deficit chart.