Marker scores for liver disease progressed in youth with HIV

  • July 22, 2014

The mean Fibrosis-4 and aspartate aminotransferase-to-platelet ratio index scores increased during time among youth with HIV compared with those without HIV, according to research presented at the International AIDS Conference in Melbourne, Australia.

Researchers compared Fibrosis-4 (FIB-4) and aspartate aminotransferase-to-platelet ratio index (APRI) scores — noninvasive surrogate markers of liver disease — in two cohorts (REACH, PACTG 219/219c) of adolescents with and without HIV. Measurements were taken and compared for patients (aged 15 to 20 years) with and without HIV who attended a single clinic visit. Researchers also assessed longitudinal trends in adolescents with HIV who went to two or more visits to compare data for those with behavioral vs. perinatal HIV infection. Among 1,780 patients in the study, 1,302 had data available from at least two clinic visits.

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