April 17, 2015
A study of the efficacy of topical platelet derived growth factor in the treatment of diabetic foot ulcers found that it did not appear to significantly improve healing in comparison with a placebo, according to results published in Wounds.
Researchers conducted a randomized, controlled trial of 46 patients with Wagner grade I ulcers and a wound area of 1 cm² to 16 cm². A fiberglass cast was applied to all participants at randomization with a window slightly larger than the study wound dimensions. Study therapy was conducted for 4 months, with a final follow-up visit scheduled after healing or 10 months after randomization if the wound was not healed at 4 months.