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Corticosteroid use linked with decreased interleukin-6 levels in patients after THA

August 28, 2016

At 6 hours and 24 hours postoperatively, patients who underwent total hip arthroplasty and received corticosteroids had a statistically significant decrease in interleukin-6 levels but not in thrombogenic markers.

Researchers randomly assigned 27 patients scheduled to undergo total hip arthroplasty (THA) to receive either 20 mg of oral prednisone 2 hours preoperatively and followed by two doses of 100-mg intravenous hydrocortisone sodium succinate taken 8 hours apart or take a placebo at the same time points. Patients had blood drawn at baseline, wound closure, 4 hours, 6 hours and 24 hours postoperatively for assays of serum interleukin-6 (IL-6), prothrombin fragment 1.2 (PF1.2) and plasmin-alpha-2-antiplasmin (PAP). Investigators also recorded patients’ in-hospital VAS pain scores, patient-controlled analgesia use and ability to climb stairs.

In the Journals

Older age associated with DVT in patients with isolated calcaneal fractures

August 27, 2016
Recently published results showed patients with isolated calcaneal fractures had an incidence of preoperative deep vein thrombosis that was almost twice as high as any…
In the Journals

Study cites gait differences between patients with non-traumatic and post-traumatic OA

August 26, 2016
Results from this study indicated patients with non-traumatic knee osteoarthritis were different from patients with post-traumatic knee osteoarthritis in regard to knee…
In the Journals

Lower pressure time integral slightly associated with increased first metatarsophalangeal pain

August 26, 2016
Recently published results showed an increased prevalence of frequent first metatarsophalangeal pain at the hallux and second metatarsal was ‘modestly’…
Blog

BLOG: Treatment options for patients with open growth plates and ACL tears

August 26, 2016
Children and adolescents continue to sustain disruptions of the ACL prior to physeal closure, which poses different challenges for reconstruction than for patients with…
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Feature Article

Incidence and Epidemiology of Patellar Fractures

Orthopedics
Online Advanced Release, August 18, 2016
The literature lacks large-scale, up-to-date, population-based epidemiology studies on the incidence of patellar…
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CME

Effect of Topical Tranexamic Acid in Reducing Bleeding and Transfusions in TKA: May 2015

Intravenous tranexamic acid (TXA) has been identified to be effective in total knee arthroplasty (TKA), but the effect…
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American Orthopaedic Foot and Ankle Society Annual Meeting 2016

American Orthopaedic Foot and Ankle Society Annual Meeting 2016

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Meeting News Coverage

VIDEO: A look at factors which lead to OA development after ACL injury, reconstruction

July 20, 2016
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