August 28, 2016
At 6 hours and 24 hours postoperatively, patients who underwent total hip arthroplasty and received corticosteroids had a statistically significant decrease in interleukin-6 levels but not in thrombogenic markers.
Researchers randomly assigned 27 patients scheduled to undergo total hip arthroplasty (THA) to receive either 20 mg of oral prednisone 2 hours preoperatively and followed by two doses of 100-mg intravenous hydrocortisone sodium succinate taken 8 hours apart or take a placebo at the same time points. Patients had blood drawn at baseline, wound closure, 4 hours, 6 hours and 24 hours postoperatively for assays of serum interleukin-6 (IL-6), prothrombin fragment 1.2 (PF1.2) and plasmin-alpha-2-antiplasmin (PAP). Investigators also recorded patients’ in-hospital VAS pain scores, patient-controlled analgesia use and ability to climb stairs.