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Synovial tissue may be immunomodulated by PMMA-spacers in two-stage revision TJA

May 29, 2015

PRAGUE — According to data presented at the 16th EFORT Congress, synovial tissue in patients undergoing two-stage revision total joint arthroplasty may be immunomodulated by polymethyl acrylate spacers.

Nicole Deutloff, MD, and colleagues evaluated 35 patients with a mean age of 67 years, of whom, nine underwent two-stage total hip arthroplasty (THA) revision and 25 underwent two-stage revision of total knee arthroplasty (TKA). Periprosthetic tissue samples were analyzed during the course of a 6-week period to determine the presence of polymethyl acrylate (PMMA) particles via Fourier transform infrared spectroscopy and microscopy, and a histological analysis was performed via Sudan Red and Haematoxylin and eosin staining. The relationship between immunophenotype and inflammatory cells was determined from CD68, CD20, CD11(c), CD3 and IL-17 antibodies, and modified Willert scores were assigned to all slides by two independent reviewers.

Vancomycin plus gentamicin-loaded spacers associated with higher microbiological eradication

Vancomycin plus gentamicin-loaded spacers associated with higher microbiological eradication

May 29, 2015
PRAGUE — Compared with use of gentamicin-loaded spacers, vancomycin plus gentamicin-loaded spacers were significantly associated with a higher microbiological…

Safe Orthopaedics announces European launch of fenestrated screws

May 29, 2015
Safe Orthopaedics recently announced the European launch of its new fenestrated screw, as well as the successful completion of the first six surgeries in patients with…
Spacer aspiration, C-reactive protein unable to determine timing for TKA Meeting News Coverage

Spacer aspiration, C-reactive protein unable to determine timing for TKA

May 28, 2015
PRAGUE — Neither spacer aspiration nor C-reactive protein-values provided a reliable method for determining the correct timing for total knee arthroplasty…
In the Journals

Extent of type 1 Modic changes associated with positive changes in low back pain

May 28, 2015
According to findings in a recently published study, the extent of type 1 Modic changes was correlated with positive changes in the Oswestry Disability Index score for…
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Case Report

Greater Trochanteric Fragmentation After Failed Metal-on-Metal Hip Arthroplasty

Orthopedics, May 2015, Volume 38 Issue 5
Adverse reaction to metal debris (ARMD) involving the hip joint has emerged as an important reason for failure and…
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CME
The Hip-Spine Connection: Understanding Its Importance in the Treatment of Hip Pathology. January 2015

The Hip-Spine Connection: Understanding Its Importance in the Treatment of Hip Pathology. January 2015

The Hip-Spine Connection: Understanding Its Importance in the Treatment of Hip Pathology
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Meeting News Coverage Video
VIDEO: Valedvit on subsidence following dynamic loading of intervertebral devices

VIDEO: Valedvit on subsidence following dynamic loading of intervertebral devices

May 21, 2015
SAN DIEGO — Antonio Valdevit, PhD, discusses a study on subsidence following dynamic loading of intervertebral…
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