May 15, 2017
Investigators of this study found fibrous synovium compared with adipose synovium release a greater number of mesenchymal stem cells in a suspended synovium culture model.
Researchers harvested human synovial tissue from knee joints during the total knee arthroplasty of 34 patients with osteoarthritis. Investigators suspended 1 gram of synovium with a thread in a bottle filled with 40 mL of culture medium. A 3.5-cm diameter culture dish was at the bottom of the bottle and investigators examined the culture dish after 7 days. Multipotentiality and surface epitopes were analyzed for the cells harvested. Investigators compared the number of colonies derived from the fibrous synovium and the adipose synovium.