March 4, 2015
Researchers found using tranexamic acid during spinal surgery effectively reduced blood loss, the volume of blood transfused, the overall rate of transfusions and the postoperative partial thromboplastic time, according to study results.
Using three separate databases, the researchers conducted a search through October 2012 to identify relevant randomized, controlled trials involving the use of tranexamic acid (TXA) during spinal surgery. The researchers extracted and compared the mean differences of blood loss, blood transfusion and thrombotic complications for a TXA-treated group of patients with a placebo group and combined the data using random-effect meta-analysis. Six randomized, controlled studies comprising a total of 411 patients were included in the analysis.