August 22, 2014
PRK combined with corneal collagen cross-linking had a transient effect on corneal innervation and a significant effect on keratocyte density for up to 4 years postoperatively, researchers found.
The researchers prospectively analyzed 17 eyes of 17 patients with progressive keratoconus who underwent PRK with corneal collagen cross-linking. Confocal microscopy was used preoperatively and 1, 3, 6, 12, 18 and 48 months postoperatively to assess corneal morphology. Primary study outcome measures were mean superficial epithelial cell density, mean basal epithelial cell density and mean anterior and mid/posterior keratocyte density. Stromal backscatter, sub-basal and stromal nerve density, and mean endothelial cell density were also evaluated.