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Next-generation DNA sequencing may have capability to detect congenital cataracts

December 17, 2014

Next-generation DNA sequencing demonstrated the capability to alter clinical management, direct care pathways and enable accurate genetic counseling in the diagnosis of bilateral congenital cataract, according to a study.

The study included 36 patients who were diagnosed with nonsyndromic or syndromic bilateral congenital cataract. Patients underwent an ophthalmic examination as well as dysmorphology assessment as needed.

DNA sequencing determined the cause of congenital cataract in 75% of patients; 85% of patients with nonsyndromic congenital cataract were likely to have pathogenic mutations and 63% of patients had potential disease-causing mutations, the study said.

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Controversies in pterygium surgery

December 17, 2014
NEW YORK — At OSN New York, William B. Trattler, MD, dispels misconceptions about pterygium surgery.
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How aligned are your partners and staff?

December 17, 2014
“Align: verb; to arrange things so that they form a line or are in a proper position; to change (something) so that it agrees with or matches something…

Actavis’ newly appointed senior management team effective after Allergan acquisition

December 16, 2014
Actavis announced that the company’s newly appointed management team will become effective immediately after the anticipated successful close of the Allergan…
In the JournalsPerspective

Treat-and-extend AMD regimen sustains outcomes for up to 3 years

December 16, 2014
A treat-and-extend protocol improved vision and reduced retinal thickness for up to 3 years in patients with neovascular age-related macular degeneration, according to…
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Choroidal Melanoma in Children: Be Aware of Risks

Journal of Pediatric Ophthalmology and Strabismus, Volume -2147483648
Online Only, December 12, 2014
The authors describe a case of choroidal melanoma in a 13-year-old girl treated with plaque brachytherapy. Uveal…
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CME
Hariprasad

In Focus: Advances in AMD – Clinical Case: Starting therapy in a patient newly diagnosed with wet AMD

This activity is supported by an educational grant from Genentech, Inc.

Successful early treatment of wet age-related macular degeneration offers the best odds for maintaining visual acuity…
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Treating residual astigmatism after toric IOL

December 16, 2014
NEW YORK — At OSN New York, John P. Berdahl, MD, discusses how he treats patients with residual astigmatism caused by…
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