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Gene therapy may improve visual function in retinal degeneration caused by RPE65 mutations

April 29, 2016

An adeno-associated virus vector improved one or more measures of visual function in patients with retinal degeneration resulting from RPE65 mutations.

Investigators set out to assess the safety of rAAV2-CB-hRPE65, a recombinant adeno-associated virus vector expressing RPE65, a 65-kDa isomerohydrolase produced by retinal pigment epithelium cells. Mutations of RPE65 are believed to result in a severe deficiency of active chromophore and can cause Leber congenital amaurosis and severe early childhood-onset retinal dystrophy.


VIDEO: Retrieving and re-fixating a dropped lens

April 29, 2016
The video describes a personal method of rescuing and re-fixating an IOL that has dropped to the retina, using two quite unique surgical maneuvers.Maneuver number 1
Meeting News CoverageVideo

VIDEO: Current treatment options for DME

April 29, 2016
At Hawaiian Eye, Elias Reichel, MD, talks about current treatment options for patients with diabetic macular edema.
From OSN Europe

Oculus releases keratoconus grading software for Pentacam

April 29, 2016
The Belin ABCD keratoconus staging capability is now available for the Pentacam, Oculus announced in a press release.The new tomographic classification and staging…
In the JournalsFrom OSN Europe

European heritage linked to increased risk of optic disc hemorrhage

April 28, 2016
European descent was associated with a higher risk of optic disc hemorrhage than African descent, and African descent was associated with greater prevalence of beta-zone…
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Clinical Science

Visualizing Macular Structures During Membrane Peeling Surgery With an Intraoperative Spectral-Domain Optical Coherence Tomography Device

Ophthalmic Surgery, Lasers and Imaging Retina, April 2016, Volume 47 Issue 4
The aim of this study was to examine the quality of intraoperative visualization of the posterior hyaloid, epiretinal…
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Central and Branch Retinal Vein Occlusion Clinical Trials: A Comprehensive Review

This activity is supported by educational grants from Allergan, Inc.; Genentech, Inc.; and Regeneron Pharmaceuticals, Inc.

The advent of intravitreal therapies to treat retinal diseases has revolutionized the management of retinal pathology…
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Highlights from the Hawaiian Eye/Retina meeting

Highlights from the Hawaiian Eye/Retina meeting

Meeting News Coverage

VIDEO: Principles of OCT angiography

April 26, 2016
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