Clinical Science 

The Use of Spectral-Domain Optical Coherence Tomography for Differentiating Long-standing Central Retinal Artery Occlusion and Nonarteritic Anterior Ischemic Optic Neuropathy

Gad Dotan, MD; Dafna Goldenberg, MD; Anat Kesler, MD; Elvira Naftaliev, MD; Anat Loewenstein, MD; Michaella Goldstein, MD



To report on the efficacy of macular and optic nerve spectral-domain optical coherence tomography (SD-OCT) in differentiating between long-standing central retinal artery occlusion (CRAO) and nonarteritic anterior ischemic optic neuropathy (NAION).


SD-OCT scans of the macula and optic nerve in 24 patients with unilateral optic atrophy secondary to CRAO (12 patients) and NAION (12 patients) were compared both qualitatively and quantitatively for differentiating features.


In patients with long-standing CRAO, there was a significantly greater (P < .001) thinning of the macula relative to the fellow uninvolved eye (–59.7 ± 31.8 μm) compared to patients with longstanding NAION (–19.9 ± 8.4 μm) even though both conditions caused a similar (P = .726) degree of peripapillary retinal nerve fiber layer loss (−42.4 ± 18.5 μm and −44.1 ± 12.4 μm, respectively).


SD-OCT macular scans can be used as an adjunctive tool for differentiating between longstanding CRAO and NAION.

[Ophthalmic Surg Lasers Imaging Retina. 2014;45:38–44.]

From the Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

The authors have no financial or proprietary interest in the materials presented herein.

Address correspondence to Gad Dotan, MD, Department of Ophthalmology, Tel Aviv Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel; 972-3-6925773; fax: 972-3-6925693, email:

Received: September 13, 2013
Accepted: November 04, 2013



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