To describe the corneal endothelial cell characteristics after pediatric cataract surgery.
Retrospective case series of 29 study eyes and 26 controls were evaluable. Specular microscopy was performed and endothelial cell features were correlated with clinical and surgical features.
Mean age at testing was 106 months in the study group and 116 months in the control group with a mean interval of 78 months after cataract surgery. Mean endothelial cell density in study eyes was 2,668 cells/mm
(control eyes, 3,002 cells/mm
< .01). Mean coefficient of variation was 35% (control eyes, 31%,
< .01), and mean percentage of hexagonal cells was 40% (control eyes, 51%,
< .01). There was no significant difference based on age, duration since cataract surgery, contact lens use, glaucoma, number of intraocular procedures, or presence of intraocular lens.
This study demonstrates endothelial cell loss with polymegathism and pleomorphism in children undergoing cataract surgery. This poses a risk of developing long-term corneal complications and hence close monitoring of the endothelial cell count is advisable.
[J Pediatr Ophthalmol Strabismus 2013;50(4):251–254.]
From the Department of Ophthalmology, Boston Children’s Hospital, Boston, Massachusetts.
The authors have no financial or proprietary interest in the materials presented herein.
Correspondence: Aparna Ramasubramanian, MD, Department of Ophthalmology, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115. E-mail:
Received: September 10, 2012
Accepted: April 09, 2013
Posted Online: June 11, 2013