Original Article 

Corneal Endothelial Cell Characteristics After Pediatric Cataract Surgery

Aparna Ramasubramanian, MD; Iason Mantagos, MD; Deborah K. Vanderveen, MD

  • Journal of Pediatric Ophthalmology and Strabismus
  • July/August 2013 - Volume 50 · Issue 4: 251-254
  • DOI: 10.3928/01913913-20130604-01

Abstract

Purpose:

To describe the corneal endothelial cell characteristics after pediatric cataract surgery.

Methods:

Retrospective case series of 29 study eyes and 26 controls were evaluable. Specular microscopy was performed and endothelial cell features were correlated with clinical and surgical features.

Results:

Mean age at testing was 106 months in the study group and 116 months in the control group with a mean interval of 78 months after cataract surgery. Mean endothelial cell density in study eyes was 2,668 cells/mm 2 (control eyes, 3,002 cells/mm 2 , P < .01). Mean coefficient of variation was 35% (control eyes, 31%, P < .01), and mean percentage of hexagonal cells was 40% (control eyes, 51%, P < .01). There was no significant difference based on age, duration since cataract surgery, contact lens use, glaucoma, number of intraocular procedures, or presence of intraocular lens.

Conclusions:

This study demonstrates endothelial cell loss with polymegathism and pleomorphism in children undergoing cataract surgery. This poses a risk of developing long-term corneal complications and hence close monitoring of the endothelial cell count is advisable.

[J Pediatr Ophthalmol Strabismus 2013;50(4):251–254.]

From the Department of Ophthalmology, Boston Children’s Hospital, Boston, Massachusetts.

The authors have no financial or proprietary interest in the materials presented herein.

Correspondence: Aparna Ramasubramanian, MD, Department of Ophthalmology, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115. E-mail: aparnaramasubramanian@gmail.com

Received: September 10, 2012
Accepted: April 09, 2013
Posted Online: June 11, 2013

10.3928/01913913-20130604-01

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