- Ophthalmic Surgery, Lasers and Imaging
- July/August 2012 - Volume 43 · Issue 4: 291-295
BACKGROUND AND OBJECTIVE:
Chronic macular hole and inability to maintain prone positioning remain poor prognostic markers for successful macular hole closure. The authors revisited the role of autologous platelets as an adjunct to internal limiting membrane (ILM) peeling of chronic macular holes in patients unable to maintain prone positioning.
PATIENTS AND METHODS:
A retrospective case study was conducted on 13 eyes of 13 patients with full-thickness chronic macular hole (> 24 months). Each patient was unable to maintain prone positioning due to medical and physical comorbidities. Each eye was treated with pars plana vitrectomy, ILM peeling, autologous platelets, and C3F8 gas tamponade. No positioning was advised postoperatively. All patients had complete ophthalmic examinations preoperatively and 1 day and 1, 3, and 6 months postoperatively with optical coherence tomography. Outcome measures were anatomic closure based on Tornambe classification, final best-corrected visual acuity, and improvement of quality of vision.
All 13 patients completed 6 months’ follow-up. Macular hole duration ranged from 2 to 5 years. There was a 100% macular hole closure rate at 1 and 6 months postoperatively. All patients reported subjective improvement in visual acuity as an improvement of an absolute central scotoma. At 6 months postoperatively, 38% of patients reported improved best-corrected visual acuity. There were no recurrences.
Autologous platelets and ILM peeling may function synergistically to enhance chronic macular hole closure in patients unable to maintain prone positioning.
From the Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch at Galveston, Galveston, Texas.
Supported by a departmental grant by Research to Prevent Blindness, Inc., New York, New York.
The authors have no financial or proprietary interest in the materials presented herein.
Address correspondence to Kapil G. Kapoor, MD, Department of Ophthalmology and Visual Sciences, 301 University Boulevard, Galveston, TX 77555. E-mail: Kaps2003@gmail.com
Received: July 18, 2011
Accepted: February 21, 2012
Posted Online: May 03, 2012