- Ophthalmic Surgery, Lasers and Imaging
The response to combined laser photocoagulation and a single intravitreal injection of 0.75 mg bevacizumab to each eye on separate days in two patients with aggressive, posterior retinopathy of prematurity (ROP) is described. Combined treatment resulted in regression of zone-1 disease in Case 1, which had no retinal detachment. However, no significant regression or unfavorable anatomic response was observed in the second case with retinal detachment. Although the combination of laser photocoagulation and intravitreal bevacizumab injection seems to be well tolerated, inducing prompt regression of agressive zone-1 ROP without retinal detachment, further controlled studies with long-term follow-up are necessary for their use in the treatment of ROP with for potentially dangerous growth factor inhibitors in premature babies.
From Gülhane Military Medical Academy and Medical School, Ankara, Turkey
Presented in part at the Winter Symposium of the Turkish Ophthalmic Society, January 18–20, 2008, Antalya, Turkey.
The authors have no financial or proprietary interest in the materials presented herein.
Address correspondence to Fatih M. MUTLU, MD, Gülhane Military Medical Academy & Medical School, Department of Ophthalmology, 06018 Etlik-Ankara, Turkey