- Journal of Pediatric Ophthalmology and Strabismus
- March/April 2012 - Volume 49 · Issue 2: 120-124
The authors hypothesized that circulating visfatin concentrations in preterm infants might be linked with retinopathy of prematurity (ROP)-like insulin-like growth factor I (IGF-I) levels.
The study group comprised 88 children born with a gestational age younger than 32 weeks between 2007 and 2009 who were screened and/or treated for ROP. The authors collected fetal cord blood (sample 1) and a blood sample at 4 to 6 weeks postnatal age (sample 2) for laboratory investigations.
The non-ROP group had higher visfatin-1, visfatin-2, insulin-1, insulin-2, (IGF-I)-1, and (IGF-I)-2 levels than the ROP group (P < .001 for all levels). Change in visfatin was positively correlated with change in IGF-I and change in insulin (P < .001 and P < .001, respectively). Change in IGF-I was positively correlated with change in insulin (P < .001).
Similar to IGF-I levels, determination of visfatin levels can be a predictive marker of ROP, but more studies are needed.
From the Division of Neonatology (FC, FEC, MÇ, SUS), Department of Pediatrics, Gulhane Military Medical Academy, Ankara; and the Departments of Pediatrics (OP, SA), Ophthalmology (OMC), and Biochemistry (OMI), Haydarpasa Military Hospital, Gulhane Military Medical Academy, Istanbul, Turkey.
The authors have no financial or proprietary interest in the materials presented herein.
Address correspondence to Ferhat Cekmez, MD, GATA Medical Faculty, Department of Neonatology, Ankara, Turkey. E-mail: email@example.com