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Gene therapy yields ‘modest’ impact on retinal sensitivity in Leber’s congenital amaurosis

May 5, 2015

Gene therapy resulted in a modest and temporary improvement in retinal sensitivity among patients with Leber’s congenital amaurosis, according to a study.

In a phase 1/2 open-label trial, 12 patients with early-onset, severe retinal dystrophy caused by mutations in RPE65 underwent gene therapy with a recombinant adeno-associated virus 2/2 (rAAV2/2) vector, rAAV2/2.hRPE65p.hRPE65, carrying RPE65 complementary DNA.

VIDEO: Study shows cataract surgery safe in patients undergoing anti-VEGF therapy Meeting News CoverageVideo

VIDEO: Study shows cataract surgery safe in patients undergoing anti-VEGF therapy

May 5, 2015
DENVER — At the Association for Research in Vision and Ophthalmology meeting here, Andrew Moshfeghi, MD, discusses his poster presentation on a sub-group analysis from…
VIDEO: Frank G. Holz, MD, receives Heidelberg Engineering’s Xtreme Research Award Meeting News CoverageVideo

VIDEO: Frank G. Holz, MD, receives Heidelberg Engineering’s Xtreme Research Award

May 5, 2015
DENVER — At the Association for Research in Vision and Ophthalmology meeting here, Frank G. Holz, MD, discusses the Xtreme Research Award and the latest research into…
VIDEO: Study shows improvement in diabetic retinopathy with ranibizumab Meeting News CoverageVideo

VIDEO: Study shows improvement in diabetic retinopathy with ranibizumab

May 5, 2015
DENVER — At the Association for Research in Vision and Ophthalmology meeting here, Jennifer K. Sun, MD, discusses the effect of ranibizumab on diabetic retinopathy in…
Meeting News Coverage

Ultra-widefield imaging increases diabetic retinopathy detection

May 5, 2015
DENVER — Ultra-widefield imaging may double diabetic retinopathy detection and referral rates while decreasing the ungradable rate in telemedicine programs…
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Practical Retina

Comparing Aflibercept, Bevacizumab, and Ranibizumab for DME: Analysis of DRCR Protocol T

Ophthalmic Surgery, Lasers and Imaging Retina, March 2015, Volume 46 Issue 3
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CME
Challenges and Solutions in Retinal Vascular Disease: Pigment Epithelial Detachment and Refractory Diabetic Macular Edema

Challenges and Solutions in Retinal Vascular Disease: Pigment Epithelial Detachment and Refractory Diabetic Macular Edema

This activity is supported by an educational grant from Regeneron Pharmaceuticals, Inc.

With anti-VEGF therapy well-established as front-line therapy in the management of age-related macular degeneration and…
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Meeting News Coverage Video
VIDEO: Frank G. Holz, MD, receives Heidelberg Engineering’s Xtreme Research Award

VIDEO: Frank G. Holz, MD, receives Heidelberg Engineering’s Xtreme Research Award

May 5, 2015
DENVER — At the Association for Research in Vision and Ophthalmology meeting here, Frank G. Holz, MD, discusses the…
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