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SPK-RPE65 meets primary endpoint in phase 3 pivotal trial

October 5, 2015

SPK-RPE65, a potential gene therapy treatment for RPE65-mediated inherited retinal dystrophies, has met its primary endpoint of demonstrating improvement in visual function as measured by the change in bilateral mobility testing between baseline and 1 year in a phase 3 pivotal trial, according to a press release from Spark Therapeutics.

Patients who received SPK-RPE65 outperformed controls in the two secondary endpoints of full-light sensitivity threshold testing (P < .001) and mobility test change score for the first injected eye (P = .001). The third secondary endpoint of visual acuity did not have statistically significant evidence of benefit, the release said.

Darrell White Blog

BLOG: The AAO 2015 marketplace

October 5, 2015
The AAO convention in Vegas is just around the corner. Are you ready?All kinds of stuff are for sale at our biggest trade show. A couple thousand people will be there…
Breaking News

Encore Vision begins enrollment for phase 1/2 study of presbyopia drug

October 5, 2015
The first patient has been enrolled in Encore Vision’s phase 1/2 trial of EV06, an investigational topical treatment for presbyopia, according to a company press…
Carlos Rodriguez-Galindo In the Journals

Poor retinoblastoma outcomes associated with racial, socioeconomic factors

October 5, 2015
Significant racial, ethnic and socioeconomic disparities appeared to exist in the care and outcome of pediatric patients with retinoblastoma, according to the results of…
Ken Beckman

Publication Exclusive: Should industry have a role in resident education?

October 5, 2015
Welcome to CEDARS/ASPENS Debates, a monthly feature in Ocular Surgery News.CEDARS (Cornea, External Disease, and Refractive Surgery Society) and ASPENS (American…
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Practical Retina

Comparing Aflibercept, Bevacizumab, and Ranibizumab for DME: Analysis of DRCR Protocol T

Ophthalmic Surgery, Lasers and Imaging Retina, March 2015, Volume 46 Issue 3
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Diabetic Eye Cover Image

Diabetic Eye 2015: New Concepts in Screening, Managing, and Referral

This activity is supported by an educational grant from Allergan, Inc.

Despite a number of effective treatment options, diabetic eye disease is a leading cause of vision loss in the United…
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Meeting News Coverage Video
VIDEO: Speaker discusses strategies for treating patients with ocular trauma

VIDEO: Speaker discusses strategies for treating patients with ocular trauma

October 1, 2015
NICE, France — At the Euretina meeting, Sundaram Natarajan, MD, gives highlights from the symposium, Newer…
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