SAN FRANCISCO — Doubling of insulin resistance was associated with a 10% to 14% decrease in bone strength among participants in the Biomarker Project of the Midlife in the United States Study.
To determine whether insulin resistance has negative effects on bone remodeling and results in reduced bone strength relative to load, Preethi Srikanthan, MD, MS, of the University of California Los Angeles, and colleagues analyzed data for 634 nondiabetic participants in the MIDUS II study. Insulin resistance was calculated using HOMA-IR, and projected 2D bone mineral density in the lumbar spine and left hip were measured using DXA. Additionally, researchers used the hip DXA scans to measure length and width at the femoral neck axis (FNAL and FNW, respectively). More »