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Synovial tissue may be immunomodulated by PMMA-spacers in two-stage revision TJA

May 29, 2015

PRAGUE — According to data presented at the 16th EFORT Congress, synovial tissue in patients undergoing two-stage revision total joint arthroplasty may be immunomodulated by polymethyl acrylate spacers.

Nicole Deutloff, MD, and colleagues evaluated 35 patients with a mean age of 67 years, of whom, nine underwent two-stage total hip arthroplasty (THA) revision and 25 underwent two-stage revision of total knee arthroplasty (TKA). Periprosthetic tissue samples were analyzed during the course of a 6-week period to determine the presence of polymethyl acrylate (PMMA) particles via Fourier transform infrared spectroscopy and microscopy, and a histological analysis was performed via Sudan Red and Haematoxylin and eosin staining. The relationship between immunophenotype and inflammatory cells was determined from CD68, CD20, CD11(c), CD3 and IL-17 antibodies, and modified Willert scores were assigned to all slides by two independent reviewers.

In the Journals

Cognitive skills decrease with history of severe infections

May 29, 2015
A history of severe infections may be associated with impaired general cognitive ability, according to recently published data. “Infections have previously been…
In the Journals

Cognitive skills decrease with history of severe infections

May 29, 2015
A history of severe infections may be associated with impaired general cognitive ability, according to recently published data.“Infections have previously been…
Drug Pipeline

Merck submits new drug application for grazoprevir/elbasvir for HCV

May 29, 2015
Merck announced that the company has submitted a new drug application to the FDA for grazoprevir/elbasvir for the treatment of adults with chronic hepatitis C genotype…
Vancomycin plus gentamicin-loaded spacers associated with higher microbiological eradication

Vancomycin plus gentamicin-loaded spacers associated with higher microbiological eradication

May 29, 2015
PRAGUE — Compared with use of gentamicin-loaded spacers, vancomycin plus gentamicin-loaded spacers were significantly associated with a higher microbiological…
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CME
Management of Pediatric Conjunctivitis and Otitis/Conjunctivitis Syndrome

Management of Pediatric Conjunctivitis and Otitis/Conjunctivitis Syndrome

This activity is supported by an educational grant from Alcon Research, LTD.

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Meeting News Coverage Video
VIDEO: C-SURFER: Patients with kidney disease, HCV achieve high rates of SVR

VIDEO: C-SURFER: Patients with kidney disease, HCV achieve high rates of SVR

April 25, 2015
VIENNA — Howard Monsour Jr., MD, chief of hepatology, Houston Methodist Hospital, Texas, discussed results of…
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CME
HCV VOICE

HCV VOICE II: Optimizing Virological Outcomes with Integrated HCV Education

This activity is supported by an educational grant from Janssen Therapeutics, Division of Janssen Products, LP.

Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis, end-stage liver disease, hepatocellular…
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