May 29, 2015
PRAGUE — According to data presented at the 16th EFORT Congress, synovial tissue in patients undergoing two-stage revision total joint arthroplasty may be immunomodulated by polymethyl acrylate spacers.
Nicole Deutloff, MD, and colleagues evaluated 35 patients with a mean age of 67 years, of whom, nine underwent two-stage total hip arthroplasty (THA) revision and 25 underwent two-stage revision of total knee arthroplasty (TKA). Periprosthetic tissue samples were analyzed during the course of a 6-week period to determine the presence of polymethyl acrylate (PMMA) particles via Fourier transform infrared spectroscopy and microscopy, and a histological analysis was performed via Sudan Red and Haematoxylin and eosin staining. The relationship between immunophenotype and inflammatory cells was determined from CD68, CD20, CD11(c), CD3 and IL-17 antibodies, and modified Willert scores were assigned to all slides by two independent reviewers.