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Prolonged neonatal antibiotic therapy decreases yet remains associated with adverse outcomes

Prolonged neonatal antibiotic therapy decreases yet remains associated with adverse outcomes
May 1, 2016

BALTIMORE — Although overall prolonged exposure to antibiotics decreased among extremely low birth weight patients over time, exposure varied significantly between neonatal centers and continues to be associated with mortality, according to research data presented at the Pediatric Academic Societies Meeting.

“While neonatologists often prescribe a prolonged initial course of antibiotics to premature infants due to fear of early-onset sepsis, it has been shown previously that exposure to a prolonged course of antibiotics was associated with increased risk of death, necrotizing enterocolitis and late-onset sepsis,” Rachel G. Greenberg, MD, a fellow in training at Duke University Medical Center, told Infectious Diseases in Children. “The goal of this study was to determine whether the prevalence of prolonged initial antibiotic exposure in premature infants has changed over time and whether it remains associated with negative outcomes.”

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