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Temporal mutation profile discerns which patients with HBV will develop HCC

July 25, 2016

Researchers from Taiwan developed a temporal mutation profile that discerned which patients with hepatitis B virus are more likely to develop hepatocellular carcinoma within 5 years, according to recent findings published in Hepatology.

“Here, we show a set of 10 HBV-[single nucleotide polymorphisms (SNPs)] associated with a statistically increased risk for HCC, each with a greater than 1.8-fold OR value after taking into account HBV genotype,” Ming-Whei Yu, PhD, professor of epidemiology and preventive medicine at National Taiwan University College of Public Health, and colleagues wrote. “Our whole viral genome analysis highlights the importance of progressive accumulation of a set of HBV mutations for hepatitis B progression to HCC in addition to well-established predictors such as HBV genotype and viral load.”

FDA News

Merck's Ebola vaccine granted breakthrough therapy status

July 25, 2016
Merck announced today that its investigational Ebola vaccine, V920, was granted breakthrough therapy designation by the FDA. The vaccine also was granted priority
Meeting News Coverage

Targeted care program improves engagement, HIV suppression in female sex workers

July 25, 2016
An HIV and sexual health intervention conducted among female sex workers in Zimbabwe appears to have increased engagement in health services and reduced the proportion…
Meeting News Coverage

PEPFAR, partners award $85 million to 56 entities to reduce HIV

July 24, 2016
The President’s Emergency Plan for AIDS Relief, or PEPFAR, along with Janssen Pharmaceuticals and ViiV Healthcare awarded $85 million to 56 DREAMS Innovation…

AASLD/IDSA update HCV guidance

July 23, 2016
The American Association for the Study of Liver Diseases and the Infectious Diseases Society of America have released updated guidelines on their website for the…
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CME

Rapid Response from Barcelona: New Data in HCV Treatment

This activity is supported by an educational grant from AbbVie and Merck & Co., Inc.

Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis, end-stage liver disease, hepatocellular…
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GI Bookshelf

Chapter 6: Nutrients To Nourish The Organisms: Prebiotics And Fiber

From Probiotics: A Clinical Guide
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VIDEO: Long-acting agents may increase number of patients on therapy, bring new people into care

July 13, 2016
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