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Patients with complicated intra-abdominal infections achieved clinical response with eravacycline

December 19, 2014

Positive preliminary results from the phase 3 IGNITE 1 trial indicate that eravacycline is non-inferior to ertapenem in achieving clinical response in patients with complicated intra-abdominal infections, the manufacturer announced.

Eravacycline (Tetraphase Pharmaceuticals) is a broad-spectrum intravenous and oral antibiotic in development in the Investigating Gram-negative Infections Treated with Eravacycline (IGNITE) program, which includes two ongoing phase 3 clinical trials: IGNITE 1 for the indication of complicated intra-abdominal infections and IGNITE 2 for complicated urinary tract infections, according to a press release. The FDA has designated eravacycline as a qualified infectious disease product for both indications.

Liver fibrosis, cirrhosis progressed faster in patients with HCV In the Journals

Liver fibrosis, cirrhosis progressed faster in patients with HCV

December 19, 2014
Veterans positive for hepatitis C virus infection were more likely to be diagnosed with liver fibrosis or cirrhosis after seroconversion compared with those who were…
In the Journals

CD4 counts lower in occasional heroin users with HIV

December 19, 2014
Occasional heroin use, as opposed to persistent or no use, could lead to lower CD4 counts in people with HIV, according to recent data. “This manuscript…
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CDC's 10 most important public health challenges of 2014

December 18, 2014
In a year that has been fraught with public health crises, the CDC has had more than its share of important work to do. While 2014’s Ebola epidemic dominated…

DOJ indicts 14 involved with 2012 fungal meningitis outbreak

December 18, 2014
Fourteen people were indicted in connection with the 2012 fungal meningitis outbreak caused by contaminated vials of injectable steroids, according to the Department…
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HCV Consults: Volume 1, Number 3

HCV Consults: Volume 1, Number 3

This activity is supported by educational grants from AbbVie and Genentech, Inc.

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Student education, immunization requirements necessary to prevent outbreaks on college campuses

November 28, 2014
NEW YORK — James C. Turner, MD, executive director of the department of student health and the National Social…
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CME
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Regimen Selection in HIV: Considering New Options to Optimize Outcomes

This activity is supported by an educational grant from Gilead Sciences Medical Affairs.

More than two decades into the antiretroviral therapy (ART) era, there are numerous options for HIV treatment. The goal…
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