February 8, 2016
Miltefosine was well-tolerated and effectively treated complicated Old World cutaneous and mucosal leishmaniasis, making it an ideal first-line treatment option, according to findings published in Open Forum Infectious Diseases.
There are four compounds that currently are available to treat leishmaniasis, a parasitic disease transmitted through bites of infected sand flies, according to the CDC. The compounds include parenterally administered pentavalent antimonial and amphotericin B, and orally administered fluconazole and miltefosine. Due to a lack of clinical trials comparing the efficacy of the agents, physicians typically assign treatment regimens based on personal experience, drug availability and cost, according to Vincent Mosimann, MD, from the Swiss Tropical and Public Health Institute, and colleagues.