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Smaller IPV dose yielded noninferior titers in HIV patients

January 24, 2015

A 40% dose of intradermal inactivated polio vaccine achieved noninferior antibody responses in HIV patients compared with a full dose administered intramuscularly, according to the results of a randomized controlled trial.

“We conducted this study in HIV-infected adults because they have suboptimal responses to many vaccines even with well-controlled HIV infection, a finding felt to be related to chronic immune activation,” the researchers wrote in the Journal of Infectious Diseases. “Consequently, we felt that this population could function as a surrogate for populations in the developing world with suboptimal vaccine responses.” The researchers evaluated the inactivated polio vaccine (IPV) in 231 adult HIV patients with well-controlled disease (viral load<400 copies/mL) who were being treated at the Eastern Virginia Medical School HIV clinic in Norfolk, Va., between Sept. 7, 2012 and July 8, 2013.

Karen Midthun FDA News

FDA approves Bexsero for serogroup B meningococcal disease

January 23, 2015
The FDA today approved the recombinant vaccine, Bexsero, for prevention of Neisseria meningitidis serogroup B among individuals aged 10 to 25 years.Bexsero (Novartis)…
In the Journals

Ebola virus mutations may hinder new treatments

January 23, 2015
Researchers have identified a genomic drift in the Ebola virus that may interfere with experimental treatments that were designed based on genetic sequences derived…
Breaking News

Disneyland measles outbreak spreads; AAP urges vaccination

January 23, 2015
The California Department of Public Health has confirmed 59 cases of measles among California residents that are linked to Disneyland or Disney California Adventure…
Health Care Legislative and Regulatory Update

New year, new code: How to get paid for chronic care management in 2015, part 3

January 23, 2015
Beginning in 2015, physicians and other qualified health care professionals will be able to separately bill Medicare for providing non-face-to-face chronic care…
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CME CNE CPE Video
Advances in Pharmacokinetic Enhancers in HIV Treatment: What You Need to Know to Optimize Outcomes

Advances in Pharmacokinetic Enhancers in HIV Treatment: What You Need to Know to Optimize Outcomes

This activity is supported by an educational grant from Bristol-Myers Squibb.

Protease inhibitors (PIs) have played an instrumental role in decreasing mortality andmorbidity among HIV-infected…
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Meeting News Coverage Video
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Student education, immunization requirements necessary to prevent outbreaks on college campuses

November 28, 2014
NEW YORK — James C. Turner, MD, executive director of the department of student health and the National Social…
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CME
Regimen Selection in HIV

Regimen Selection in HIV: Considering New Options to Optimize Outcomes
Monograph

This activity is supported by an educational grant from Gilead Sciences Medical Affairs.

More than 2 decades into the antiretroviral therapy (ART) era, numerous options are available for HIV treatment. The…
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