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Letermovir effective as prophylaxis for CMV in high-risk HCT patients

Letermovir effective as prophylaxis for CMV in high-risk HCT patients
February 22, 2017

Letermovir was highly effective in a phase 3 trial at preventing infection with cytomegalovirus, or CMV, in patients who underwent allogeneic hematopoietic cell transplantation who were CMV–seropositive at the time of transplant. Additionally, the drug was well-tolerated overall, with side effects comparable to placebo.

CMV is a common complication of hematopoietic cell transplantation (HCT) and has been the focus of a decades-long search for an effective prophylaxis, explained Francisco Marty, MD, associate professor of medicine at Harvard Medical School and attending physician in transplant and oncology infectious diseases at Dana-Farber Cancer Institute and Brigham and Women’s Hospital.

Perspective

IDSA guidelines address health care–associated ventriculitis, meningitis

February 21, 2017
The Infectious Diseases Society of America has released new guidelines on detecting and treating ventriculitis and meningitis occurring after invasive procedures…
In the Journals PlusPerspective

B. cepacia outbreak yields pointers for multi-institutional response

February 21, 2017
A 2016 outbreak of Burkholderia cepacia has left clinicians with lessons on an effective response, including sharing information among facilities and the value of a…
In the Journals Plus

Transplant recipients with nocardiosis face 10-fold greater mortality

February 20, 2017
Solid organ transplant patients with nocardiosis had a 10-fold greater 1-year mortality compared with control transplant recipients, researchers in Europe found.
CME

The Patient with Otitis Media

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Acute otitis media (AOM), a common disease of childhood, is diagnosed by careful otoscopy with an understanding of…
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Letermovir effective as prophylaxis for CMV in high-risk HCT patients

February 22, 2017
Letermovir was highly effective in a phase 3 trial at preventing infection with cytomegalovirus, or CMV, in patients…
More »
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Conference on Retroviruses and Opportunistic Infections (CROI)

Conference on Retroviruses and Opportunistic Infections (CROI)

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Meeting News Coverage

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Letermovir effective as prophylaxis for CMV in high-risk HCT patients

February 22, 2017
Letermovir was highly effective in a phase 3 trial at preventing infection with cytomegalovirus, or CMV, in patients who underwent allogeneic…

Perspective

IDSA guidelines address health care–associated ventriculitis, meningitis

February 21, 2017
The Infectious Diseases Society of America has released new guidelines on detecting and treating ventriculitis and meningitis occurring after…

In the Journals PlusPerspective

B. cepacia outbreak yields pointers for multi-institutional response

February 21, 2017
A 2016 outbreak of Burkholderia cepacia has left clinicians with lessons on an effective response, including sharing information among facilities…

In the Journals Plus

Transplant recipients with nocardiosis face 10-fold greater mortality

February 20, 2017
Solid organ transplant patients with nocardiosis had a 10-fold greater 1-year mortality compared with control transplant recipients, researchers in

In the Journals

Bloodstream infections most common type of HAI in children

February 17, 2017
A recent point-prevalence survey identified that infection control should focus on prevention of bloodstream infections, especially among neonates

Commentary

More effective CMV prophylactic therapies needed for high-risk HCT patients

Infectious Disease News, February 2017
Roy F. Chemaly, MD, MPH, FIDSA, FACP
Due to advances in diagnostic methods and the development of preventive or pre-emptive strategies, the incidence of cytomegalovirus disease after…

FDA News

FDA warns of rare, serious allergic reactions with skin antiseptic chlorhexidine gluconate

February 9, 2017
The FDA recently issued a warning to patients and health care professionals that rare but serious allergic reactions have been reported with skin…

In the Journals PlusPerspective

Higher doses of daptomycin associated with lower mortality among VRE patients

February 6, 2017
The mortality rate of patients with vancomycin-resistant enterococci bloodstream infections who were treated with daptomycin was lower among those…

CDI microbiome drug trial failure may be explained by misdiagnosis, dosing

February 1, 2017
Seres Therapeutics has revealed complete 24-week data from the phase 2 ECOSPOR trial of its investigational oral microbiome-based therapeutic…

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Exposure to patients with influenza persists despite hospital surveillance

January 30, 2017
A large community hospital in Toronto failed to diagnose one in six patients with influenza until they had exposed other patients and health care…

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