PHILADELPHIA — Adults with HIV-1 infection were
more likely to have Plasmodium parasitemia and combined parasitemia or
history of clinical malaria, according to findings from the Kericho cohort
study.
Douglas Shaffer, MD, MHS, of the US Military HIV
Research Program and Walter Reed Army Institute of Research in Kericho, Kenya,
and colleagues evaluated the association between HIV, Plasmodium
parasitemia and clinical malaria in adults participating in the 36-month
prospective study in Kenya.
Shaffer and colleagues estimated the OR for prevalence
of cases at baseline and the HR for follow-up incident cases between HIV and
two malaria outcomes (Plasmodium parasitemia and combined parasitemia
and/or history of clinical malaria).
Of 2,801 participants enrolled in the study, the
researchers identified 14.3% with HIV at baseline and 33.2% with HIV plus
parasitemia and/or clinical malaria prevalence.
Compared with non–HIV-infected participants, more
HIV-infected participants had baseline parasitemia (6% vs. 3.5%, P=.02)
and parasitemia/clinical malaria (40% vs. 31%, P,.01) with ORs of 1.73 (95% CI, 1.04-2.80) and
1.53 (95% CI, 1.22-1.91), respectively.
Overall, the researchers reported that adults with
baseline HIV were at increased risk for both incident parasitemia (HR=1.69; 95%
CI, 1.29-2.21) and parasitemia/clinical malaria (HR=1.41; 95% CI, 1.19-1.69).
For more information:
- Shaffer D. #22. Presented at: the American Society of Tropical
Medicine and Hygiene 60th Annual Meeting; Dec. 4-8, 2011; Philadelphia.
Disclosure: The researchers report no relevant
financial disclosures.