ORLANDO, Fla. — Amoxicillin dosing schedules of three or four times a day in standard triple therapy worked better at the eradication of Helicobacter pylori infection compared to the standard, empirically dosed twice-daily regimen used in Japan, according to data presented at Digestive Disease Week.
“Triple therapy with a proton pump inhibitor, amoxicillin and clarithromycin or metronidazole is the standard regimen in Japan, and the regimens are usually dosed twice daily,” Takahisa Furuta, MD, PhD, of the Center for Clinical Research at Hamamatsu University School of Medicine in Japan, said here during his presentation. “However, the efficacy of amoxicillin depends on time-above-MIC [minimum inhibitory concentrations], and should be dosed frequently to make time-above-MIC longer.”
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