Patients who were hepatitis C virus seropositive and coinfected with HIV had nearly a ninefold increased risk for liver-related death compared with patients who were HCV seronegative with no correlations to HCV viremia level or genotype in a recent study.
In a prospective study, researchers enrolled 13,025 patients (mean age, 37.5 years; 74.2% men) with HIV and known HCV antibody (HCVAb) from the EuroSIDA cohort (1994-2011) that included 18,295 HIV-1 infected patients from 105 centers in Europe, Israel and Argentina. Thirty-one percent of the patients had detectable HCVAb (n=4,044), including 3,745 who were seropositive at baseline and the remainder who initially were HCVAb negative but showed detectable anti-HCV antibodies during follow-up.
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