Infectious Disease

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Researchers find SVR from Incivek-based regimens improved liver fibrosis scores

September 4, 2015

In a retrospective analysis, researchers found that patients with hepatitis C virus infection who achieved sustained virologic response after treatment with an Incivek-based regimen showed improvement in serum markers for liver fibrosis, according to study data.

Data of 1,208 patients with HCV was collected and evaluated from the PROVE3 phase 2 clinical study and the ADVANCE and REALIZE phase 3 clinical studies that were investigating Incivek (telaprevir, Vertex Pharmaceuticals Inc.). For the analysis, all patients were divided according to severity of fibrosis measured through their baseline Metavir score, and whether or not they reached SVR after treatment. The researchers measured the patients’ scores from four biomarker tests: FibroTest, aspartate aminotransferase (AST) to Platelet Ratio Index (APRI), Fibrosis-4 (FIB-4) and Forns' Score, before and after HCV treatment.

In the Journals

Lack of awareness of HIV status prevents care for MSM, PWID in India

September 4, 2015
Among men who have sex with men and people who inject drugs in India, a lack of awareness regarding HIV-positive status is a major obstacle to facilitating care…
In the Journals

WNV most common cause of reported neuroinvasive arboviral diseases in 2014

September 3, 2015
Cases of West Nile virus were responsible for 95% of all U.S. arboviral disease reports during 2014, with neuroinvasive cases of the infection comprising more than half…
In the Journals

Reason for surge in plague cases remains unknown

September 3, 2015
A recent report in MMWR, detailing the 12 cases of human plague reported this year, noted that the reason behind the surge remains unclear.“Plague is a rare…
In the Journals

Ebola virus transmission eliminated in Liberia

September 3, 2015
It has been more than 42 days since the last patient was discharged from an Ebola treatment unit in Liberia — more than twice the length of the maximum incubation…
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CME
Infectious Disease Case Consults

The Patient with Hepatitis C

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with hepatitis C.
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At Issue Video
VIDEO: Cure is ‘next frontier’ of HIV

VIDEO: Cure is ‘next frontier’ of HIV

July 1, 2015
Timothy Brown – the Berlin patient – has led researchers to the next frontier of HIV research, according to…
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CME
Infectious Disease Case Consults

The Patient at Risk for HIV Infection

No commercial support for this activity.

This CME activity will focus on the utilization of PrEP in patients at risk for developing HIV infection supplemented…
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