February 9, 2016
Exposure to fluoroquinolone and macrolide were found to be associated with infection by the epidemic BI/NAP1/027 strain of Clostridium difficile, which is highly resistant to these antibiotics, according to recent study data.
“Antibiotic exposure is arguably the most important risk factor for C. difficile infection (CDI),” Stuart Johnson, MD, from Loyola University Health System, Loyola University Chicago Stritch School of Medicine and the Hines VA Medical Hospital, told Healio Gastroenterology. “The main role of antibiotics in the pathogenesis of CDI is likely alteration of the beneficial flora in the gut, making patients susceptible to a C. diff infection. However, another role of antibiotics highlighted in our study is that overuse of specific antibiotics may facilitate infection due to C. diff strains that are highly resistant to those antibiotics.”