Infectious Disease

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Ascletis launches phase 2 trial of interferon-free regimen for HCV

August 31, 2015

Ascletis Pharmaceuticals Co., Ltd. announced the launch of a phase 2 clinical trial in Taiwan to investigate the efficacy of its interferon-free regimen for the treatment of chronic hepatitis C virus infection, according to a press release from the manufacturer.

The clinical trial, known as the EVEREST trial, will evaluate the antiviral activity, safety and pharmacokinetics of a combination regimen of Danoprevir (ASC08), a direct-acting antiviral agent and NS3/4A inhibitor, and Ravidasvir (ASC16), an NS5A inhibitor, in treatment-naive patients with HCV genotype 1 without cirrhosis, according to the release.

Carlos del-Rio In the Journals

Key barriers block widespread protection with PrEP

August 31, 2015
Despite the potential of HIV pre-exposure prophylaxis, several barriers make it ineffective at the individual and population levels, according to researchers at Emory…
In the Journals

Readmission rates may skew hospital quality measurements

August 31, 2015
Readmission rates were an ineffective measure of a hospital’s quality because they did not take into account readmissions from different hospitals, resulting in a…
In the Journals

Responses similar to double- vs. single-dose HBV revaccination in HIV patients

August 31, 2015
Researchers found no difference in seroprotection rates between a double-dose hepatitis B virus vaccine regimen and a standard single-dose regimen in adults with HIV who…

Two dengue drugs enter phase 2 trials

August 30, 2015
Singapore’s National Medical Research Council has awarded a grant to Singapore General Hospital supporting entry of two dengue treatments — the antiviral…
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CME
Infectious Disease Case Consults

The Patient with Protozoan Illness

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with protozoan illness.
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At Issue Video
VIDEO: Cure is ‘next frontier’ of HIV

VIDEO: Cure is ‘next frontier’ of HIV

July 1, 2015
Timothy Brown – the Berlin patient – has led researchers to the next frontier of HIV research, according to…
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CME
Infectious Disease Case Consults

The Patient at Risk for HIV Infection

No commercial support for this activity.

This CME activity will focus on the utilization of PrEP in patients at risk for developing HIV infection supplemented…
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