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GS-4774 for HBV fails to meet primary endpoint in phase 2 trial

May 27, 2015

Results from a phase 2 trial of GS-4774 for the treatment of chronic hepatitis B virus infection showed that patients treated with the highest dose of the drug, in addition to ongoing oral antiviral therapy, failed to meet the study’s primary endpoint through no reduction in hepatitis B surface antigen after 24 weeks of therapy, according to a press release from the manufacturer.

The goal of the trial is to investigate GS-4774 in combination with ongoing oral antiviral treatment in patients with chronic HBV infection whose infection is currently under control with an oral antiviral therapy, according to the release. The trial enrolled 178 patients who will be randomly assigned three different doses of GS-4774 in combination with oral antiviral therapy and compared with patients receiving antiviral treatment alone.

Meeting News Coverage

Irrigation and debridement can be viable option for selected patients with periprosthetic joint infections

May 27, 2015
PRAGUE — Irrigation and debridement for the treatment of hip and knee periprosthetic joint infections is a reasonable option for selected patients and should be…

WHO prepares for potential Ebola resurgence during West African rainy season

May 27, 2015
While new Ebola cases in West Africa generally continue to decline, WHO officials said the organization will remain vigilant as it prepares for the rainy…
Meeting News Coverage

Low-grade infections a growing problem in shoulder, elbow surgeries

May 27, 2015
PRAGUE — Postoperative, low-grade infections in the shoulder and elbow are becoming a growing problem in orthopedic surgeries, a speaker reported today at the 16th…
In the Journals

Young lesbian women less likely to receive HPV vaccination

May 27, 2015
Despite being at an elevated risk for cervical cancer morbidity and mortality, young lesbians are significantly less likely to initiate HPV vaccination compared with…
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CME
Infectious Disease Case Consults

The Patient with Hepatitis C

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with hepatitis C.
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Meeting News Coverage Video
VIDEO: C-SURFER: Patients with kidney disease, HCV achieve high rates of SVR

VIDEO: C-SURFER: Patients with kidney disease, HCV achieve high rates of SVR

April 25, 2015
VIENNA — Howard Monsour Jr., MD, chief of hepatology, Houston Methodist Hospital, Texas, discussed results of…
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CME
Regimen Selection in HIV

Regimen Selection in HIV: Considering New Options to Optimize Outcomes
Monograph

This activity is supported by an educational grant from Gilead Sciences Medical Affairs.

More than 2 decades into the antiretroviral therapy (ART) era, numerous options are available for HIV treatment. The…
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