Infectious Disease

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Anemia associated with Alinia monotherapy when used longer than FDA-approved duration

Infectious Disease News, April 2015
Roula Baroudi, MD; Edward Grace, PharmD; Marquetta Flaugher, PhD, ARNP

Alinia, the first thiazolide, was approved in 2002 by the FDA for the treatment of protozoal and helminthic infections. It was hypothesized that the drug may have possible antiviral activity by increasing the phosphorylation of double-stranded RNA-dependent protein kinase and the induction of eukaryotic-initiation of factor 2-alpha, which is an important factor in the innate immune response against hepatitis C infection.

Before the introduction of the direct-acting antiviral agents in 2011, treatment for HCV consisted of combination therapy using ribavirin (RBV) and pegylated interferon (PEG-IFN). Treatment therapy of nonresponders, relapsers or patients who were not candidates for combination therapy with RBV and PEG-IFN were often offered salvage therapy with experimental drugs in an attempt to suppress the HCV and thus, halt the development of hepatocellular carcinoma.

In the Journals

WNV most common cause of reported neuroinvasive arboviral diseases in 2014

September 3, 2015
Cases of West Nile virus were responsible for 95% of all U.S. arboviral disease reports during 2014, with neuroinvasive cases of the infection comprising more than half…
In the Journals

Reason for surge in plague cases remains unknown

September 3, 2015
A recent report in MMWR, detailing the 12 cases of human plague reported this year, noted that the reason behind the surge remains unclear.“Plague is a rare…
In the Journals

Ebola virus transmission eliminated in Liberia

September 3, 2015
It has been more than 42 days since the last patient was discharged from an Ebola treatment unit in Liberia — more than twice the length of the maximum incubation…

World Hepatitis Summit aims to raise awareness of viral hepatitis

September 3, 2015
Hundreds of key leaders, policymakers and patient groups are currently attending the first-ever World Hepatitis Summit in Glasgow, Scotland, in an attempt to raise more…
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CME
Infectious Disease Case Consults

The Patient with Conjunctivitis

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with conjunctivitis.
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At Issue Video
VIDEO: Cure is ‘next frontier’ of HIV

VIDEO: Cure is ‘next frontier’ of HIV

July 1, 2015
Timothy Brown – the Berlin patient – has led researchers to the next frontier of HIV research, according to…
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CME
Infectious Disease Case Consults

The Patient at Risk for HIV Infection

No commercial support for this activity.

This CME activity will focus on the utilization of PrEP in patients at risk for developing HIV infection supplemented…
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