Transplantation

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HCC in presence of HCV decreases cure rate in DAA treatment

May 24, 2017

Patients with hepatocellular carcinoma and hepatitis C were less likely to achieve sustained virologic response while receiving direct-acting antiviral therapy compared with patients without HCC, according to results of a retrospective study.

“Our data demonstrate that the presence of active HCC at the initiation of HCV therapy is significantly associated with DAA treatment failure,” Stacey B. Prenner, MD, from Northwestern University, Chicago, and colleagues wrote. “In contrast, DAA therapy in the presence of inactive tumor or post removal of tumor (resection/transplant) resulted in excellent SVR rates, similar to patients without HCC. There may be a trade-off in optimizing HCV clearance and risk of recurrent HCC depending upon the immunologic properties of an individual tumor.”

In the Journals

Liver tumor sizes at criteria margins may be subject to inaccurate reports

May 19, 2017
Researchers found evidence suggesting that tumor sizes at the margins of hepatocellular carcinoma-related transplantation criteria may be subject to inaccurate…
In the Journals

LT priority needed for patients with MELD score greater than 40

May 18, 2017
Patients with a MELD score greater than 40 had a significantly greater liver transplantation waitlist mortality rate but comparable posttransplant survival with patients…
In the Journals

Post-LT biopsies show histologic features of HCV following SVR

May 17, 2017
Results of a retrospective analysis showed histologic changes associated with active hepatitis C in patients who had achieved sustained virologic response following…
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In the Journals

HCC in presence of HCV decreases cure rate in DAA treatment

May 24, 2017
Patients with hepatocellular carcinoma and hepatitis C were less likely to achieve sustained virologic response while receiving direct-acting…

In the Journals

Liver tumor sizes at criteria margins may be subject to inaccurate reports

May 19, 2017
Researchers found evidence suggesting that tumor sizes at the margins of hepatocellular carcinoma-related transplantation criteria may be subject to…

In the Journals

LT priority needed for patients with MELD score greater than 40

May 18, 2017
Patients with a MELD score greater than 40 had a significantly greater liver transplantation waitlist mortality rate but comparable posttransplant…

In the Journals

Post-LT biopsies show histologic features of HCV following SVR

May 17, 2017
Results of a retrospective analysis showed histologic changes associated with active hepatitis C in patients who had achieved sustained virologic…

Meeting News

Gut microbiota associated with impaired cognitive function post-LT

May 12, 2017
CHICAGO — Cognitive function improves in most patients who undergo liver transplantation for cirrhosis, according to a presentation at…

Meeting News

AIH, younger age increase risk for PSC recurrence in pediatric LT patients

May 10, 2017
CHICAGO — Researchers found that nearly a quarter of pediatric patients who underwent liver transplantation for primary sclerosing cholangitis…

Meeting News

Older donor age negatively affects survival of living donor LT recipient

May 8, 2017
CHICAGO — Older donor age in living donor liver transplantation negatively affected survival at 1 year and increased the risk of complications…

In the Journals

Hepatic steatosis resolves in most post-transplant pediatric patients

May 4, 2017
Hepatic steatosis typically develops in pediatric patients after liver transplantation, but resolves in most cases, according to results of a…

In the Journals

Everolimus reduces weight gain post-LT compared with tacrolimus

May 3, 2017
The anti-rejection drug everolimus with reduced-exposure tacrolimus resulted in less weight gain after liver transplantation than standard tacrolimus…

In the Journals

SVR achieved after transplantation with HCV-infected kidneys

May 1, 2017
In a recent pilot trial, patients who were previously hepatitis C-negative had detectable HCV RNA after transplantation with HCV-infected kidneys…

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