Steatohepatitis/Metabolic Liver Disease

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Patient characteristics differ among RTCs, observational studies in NAFLD

May 25, 2017

Participants in randomized control trials for nonalcoholic fatty liver disease had significantly different characteristics, such as age, BMI and sex, compared with patients in observational studies, according to a systematic review.

“Given the high prevalence of NAFLD, there is a need for effective therapies to prevent progression of disease and to treat established fibrosis. However, while many treatments have been trialed, few have shown categorical benefit in [nonalcoholic steatohepatitis],” Richard Parker, PhD, from the University of Birmingham, U.K., and colleagues wrote. “Poor external validity may promote ineffective treatments or, conversely, limit the acceptance of effective treatments. These data ... show that characteristics of individuals with NAFLD in [observational studies] differ from those included in [randomized control trials].”

In the Journals

Fibrosis stage, fat score increase risk for type 2 diabetes in NAFLD patients

May 25, 2017
In a retrospective study, researchers observed an association between stage 3 and 4 fibrosis and histologic fat scores in stage 0 to 2 and increased risk for type 2…
In the Journals

Alcohol abstinence may be necessary to induce changes in liver lipids

May 23, 2017
After 12 weeks of exercise without weight change or reduction of alcohol, patients with obesity who consume alcohol increased lean body mass, reduced fat mass and…
In the Journals

Hepatic steatosis worsens faster in HIV mono-infection than HIV/HCV

May 22, 2017
Hepatic steatosis progressed faster and was more often associated with liber fibrosis progression among patients with HIV mono-infection compared with patients with…
CME

HCV Updates and Case Challenges for the Rapidly Changing Landscape

This activity is supported by an educational grant from Merck & Co., Inc.

In the past few years, significant progress has been made in the treatment of chronic hepatitis C virus (HCV). Highly…
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GI Bookshelf

Chapter 4: Ear, Nose, and Throat Manifestations of GERD

From Extraesophageal Manifestations of GERD
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VIDEO: Liver disease topics discussed at DDW include HCV, NAFLD, statins

May 12, 2017
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In the Journals

Patient characteristics differ among RTCs, observational studies in NAFLD

May 25, 2017
Participants in randomized control trials for nonalcoholic fatty liver disease had significantly different characteristics, such as age, BMI and sex…

In the Journals

Fibrosis stage, fat score increase risk for type 2 diabetes in NAFLD patients

May 25, 2017
In a retrospective study, researchers observed an association between stage 3 and 4 fibrosis and histologic fat scores in stage 0 to 2 and increased…

In the Journals

Alcohol abstinence may be necessary to induce changes in liver lipids

May 23, 2017
After 12 weeks of exercise without weight change or reduction of alcohol, patients with obesity who consume alcohol increased lean body mass, reduced…

In the Journals

Hepatic steatosis worsens faster in HIV mono-infection than HIV/HCV

May 22, 2017
Hepatic steatosis progressed faster and was more often associated with liber fibrosis progression among patients with HIV mono-infection compared…

Meeting News

Regular physical activity may reduce NAFLD in adults with overweight, obesity

May 18, 2017
In adults with overweight or obesity, daily, habitual physical activity — even if not moderate to vigorous intensity — was shown to…

In the Journals

Room-temperature susceptometer noninvasively verifies liver iron

May 18, 2017
Room-temperature susceptometer offers a noninvasive method to assess liver iron and may result in increased cost efficacy compared with methods that…

In the Journals

MRE measures liver stiffness in pediatric patients with NAFLD

May 16, 2017
Magnetic resonance elastography showed potential as a noninvasive measurement of hepatic stiffness in pediatric patients with nonalcoholic fatty…

Novartis exercises option to license NASH inhibitor from Conatus

May 15, 2017
Novartis notified Conatus Pharmaceuticals of the company’s intention to exercise the option to an exclusive license agreement for the global…

In the Journals

Hepatic indices predict NAFLD in patients with type 1 diabetes

May 15, 2017
The fatty liver index and the hepatic steatosis index are effective markers for predicting liver fat content and metabolic syndrome in patients with…

Meeting NewsVideo

VIDEO: Liver disease topics discussed at DDW include HCV, NAFLD, statins

May 12, 2017
CHICAGO — In this exclusive video from Digestive Disease Week, Norah Terrault, MD, MPH, discusses the topics reviewed during a press…

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