Hepatitis C

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HCC in presence of HCV decreases cure rate in DAA treatment

May 24, 2017

Patients with hepatocellular carcinoma and hepatitis C were less likely to achieve sustained virologic response while receiving direct-acting antiviral therapy compared with patients without HCC, according to results of a retrospective study.

“Our data demonstrate that the presence of active HCC at the initiation of HCV therapy is significantly associated with DAA treatment failure,” Stacey B. Prenner, MD, from Northwestern University, Chicago, and colleagues wrote. “In contrast, DAA therapy in the presence of inactive tumor or post removal of tumor (resection/transplant) resulted in excellent SVR rates, similar to patients without HCC. There may be a trade-off in optimizing HCV clearance and risk of recurrent HCC depending upon the immunologic properties of an individual tumor.”

In the Journals

Generic ledipasvir-sofosbuvir achieved SVR12 in HCV genotype 1b

May 23, 2017
Treatment with generic ledipasvir-sofosbuvir for 8 to 12 weeks was affective in Chinese patients with hepatitis C genotype 1b, according to a recently published study…
In the Journals

Hepatic steatosis worsens faster in HIV mono-infection than HIV/HCV

May 22, 2017
Hepatic steatosis progressed faster and was more often associated with liber fibrosis progression among patients with HIV mono-infection compared with patients with…

Q&A: How to identify patients with HCV

May 19, 2017
Hepatitis Awareness Month and Hepatitis Testing Day are observed annually in May to raise awareness of the disease and encourage clinicians to test priority…
CME

HCV Updates and Case Challenges for the Rapidly Changing Landscape

This activity is supported by an educational grant from Merck & Co., Inc.

In the past few years, significant progress has been made in the treatment of chronic hepatitis C virus (HCV). Highly…
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GI Bookshelf

Chapter 5: Bowel Obstruction And Pseudo-Obstruction

From GI Emergencies: A Quick Reference Guide
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VIDEO: Viral decline, drug level measured with fine-needle aspiration

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In the Journals

HCC in presence of HCV decreases cure rate in DAA treatment

May 24, 2017
Patients with hepatocellular carcinoma and hepatitis C were less likely to achieve sustained virologic response while receiving direct-acting…

In the Journals

Generic ledipasvir-sofosbuvir achieved SVR12 in HCV genotype 1b

May 23, 2017
Treatment with generic ledipasvir-sofosbuvir for 8 to 12 weeks was affective in Chinese patients with hepatitis C genotype 1b, according to a…

In the Journals

Hepatic steatosis worsens faster in HIV mono-infection than HIV/HCV

May 22, 2017
Hepatic steatosis progressed faster and was more often associated with liber fibrosis progression among patients with HIV mono-infection compared…

Q&A: How to identify patients with HCV

May 19, 2017
Hepatitis Awareness Month and Hepatitis Testing Day are observed annually in May to raise awareness of the disease and encourage clinicians to test…

Physician groups promote CDC guide to HCV testing

May 19, 2017
To mark Hepatitis Testing Day on May 19, two physicians’ organizations are directing clinicians to the CDC’s newest guide to hepatitis C…

In the Journals

CDC: National Hepatitis C Testing Day is May 19

May 19, 2017
May 19 is the sixth annual National Hepatitis C Testing Day, a part of Hepatitis C Awareness Month. According to the CDC, many people live with…

In the Journals Plus

Harvoni safe, effective for HCV–infected patients with sickle cell disease

May 18, 2017
Harvoni, a fixed-dose combination of ledipasvir and sofosbuvir, safely and effectively treated hepatitis C virus infection in patients with sickle…

In the Journals

Generic HCV drugs may offer cost savings, not just cost efficacy

May 17, 2017
Generic direct-acting antivirals for hepatitis C virus may not only be cost effective, but save money over 10 years compared with management of the…

In the Journals

Post-LT biopsies show histologic features of HCV following SVR

May 17, 2017
Results of a retrospective analysis showed histologic changes associated with active hepatitis C in patients who had achieved sustained virologic…

The Big Picture

Peer-to-Peer: Take Small Steps to Everyday Advocacy

HCV Next, May/June
Stacey Trooskin, MD, PhD
There was never a specific moment where I said, “Today is the day I start my HCV advocacy work.” For me, it evolved as the landscape…

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