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Patient characteristics differ among RTCs, observational studies in NAFLD

May 25, 2017

Participants in randomized control trials for nonalcoholic fatty liver disease had significantly different characteristics, such as age, BMI and sex, compared with patients in observational studies, according to a systematic review.

“Given the high prevalence of NAFLD, there is a need for effective therapies to prevent progression of disease and to treat established fibrosis. However, while many treatments have been trialed, few have shown categorical benefit in [nonalcoholic steatohepatitis],” Richard Parker, PhD, from the University of Birmingham, U.K., and colleagues wrote. “Poor external validity may promote ineffective treatments or, conversely, limit the acceptance of effective treatments. These data ... show that characteristics of individuals with NAFLD in [observational studies] differ from those included in [randomized control trials].”

In the Journals

Fibrosis stage, fat score increase risk for type 2 diabetes in NAFLD patients

May 25, 2017
In a retrospective study, researchers observed an association between stage 3 and 4 fibrosis and histologic fat scores in stage 0 to 2 and increased risk for type 2…

Congressional Budget Office estimates $119 billion in savings over 10 years for House-passed AHCA

May 24, 2017
The Congressional Budget Office — a non-partisan scoring agency — and the staff of the Joint Committee on Taxation released its cost estimate for the…

Prescription drug prices rose nearly 10% in 2016

May 24, 2017
The cost of prescription drugs increased by 8.77% last year, the fourth consecutive year drug prices have gone up, according to data from the Truveris National Drug…
FDA News

FDA grants priority review to Opdivo for advanced liver cancer

May 24, 2017
The FDA granted priority review to nivolumab for the treatment of hepatocellular carcinoma, according to the drug’s manufacturer. The designation applies to use of…
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HCV Updates and Case Challenges for the Rapidly Changing Landscape

This activity is supported by an educational grant from Merck & Co., Inc.

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International Liver Congress

Video Perspective

VIDEO: AHCA still faces 'uphill battle' in Senate, speaker says

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