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Next-generation sequencing costeffective for evaluation of inherited colorectal cancer, polyposis syndromes

May 28, 2015

The use of next-generation sequencing panels that included highly penetrant genes associated with colorectal cancer and polyposis syndromes in addition to Lynch syndrome genes appeared to be cost-effective for the evaluation of colon cancer in patients’ relatives, according to study results.

“Despite the promise of next-generation sequencing, the utility of testing multiple genes with different modes of inheritance and with varying levels of disease penetrance has been questioned based on the argument that costs of increased surveillance and unnecessary treatments may outweigh the benefits of cancer prevention, as well as the uncertain consequences of the identification of variants of unknown significance,” David L. Veenstra, PharmD, PhD, of the University of Washington, and colleagues wrote. “The colorectal cancer and polyposis syndromes phenotype is an ideal model to study the cost-effectiveness of next-generation sequencing panels because … there are multiple genes associated with the overlapping clinical picture and testing under the current standard of care has unacceptable sensitivity.”

CMS proposes updated Medicaid, CHIP-managed care regulations

May 28, 2015
CMS recently proposed a rule to update managed care regulations for Medicaid and the Children’s Health Insurance Program, according to a press release.The…
In the Journals

Childhood cancer survivors likely to need federal income assistance as adults

May 27, 2015
Long-term survivors of childhood cancers are more likely to claim supplemental social security income or social security disability insurance as adults than those…
Andrew Bauer In the Journals

ATA releases first guidelines for pediatric thyroid nodules, cancer

May 27, 2015
An American Thyroid Association task force recently released guidelines for treating children with thyroid nodules and thyroid cancer that were published in…
In the Journals

Cancer diagnosis may encourage smoking cessation

May 27, 2015
The receipt of a cancer diagnosis was associated with sustained smoking cessation regardless of the cancer’s prognosis or relation to smoking, according to study…
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Low Risk AAMDS

Treatment Decision-Making through the Spectrum of MDS:
Case 1 Low Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain MDS…
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Meeting News Coverage Video
VIDEO: Updates in prostate cancer treatment options

VIDEO: Updates in prostate cancer treatment options

May 5, 2015
Robert S. DiPaola, MD, director of Rutgers Cancer Institute of New Jersey, discusses various forms of prostate cancer…
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New Advances, New Options: Evaluating the Changing Landscape of Hemophilia

New Advances, New Options: Evaluating the Changing Landscape of Hemophilia to Optimize Patient Outcomes

This activity is supported by an educational grant from Biogen Idec.

The bleeding abnormalities associated with hemophilia can have devastating consequences for patients. Recent advances…
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