Hematology/Oncology

Top Story

Surrogate endpoints may not predict OS in oncology clinical trials

August 4, 2015

A majority of trial-level validation studies of surrogate endpoints demonstrated little correlation with survival rates, according to a systematic review of trial-level meta-analyses.

“Although there is growing recognition that adopting new medical practices based on improvements in surrogate outcomes can lead to misleading conclusions, surrogate endpoints continue to play a prominent role in oncology," Vinay Prasad, MD, MPH, postdoctoral cancer prevention fellow at the NCI, and colleagues wrote. “In the U.S., most new cancer drugs are approved based on surrogate measures, such as response rate and PFS, through the FDA’s Accelerated Approval pathway.”

Hatem A. Azim, Jr., MD In the Journals

Assisted reproduction feasible for women with breast cancer history

August 4, 2015
Women with a history of breast cancer can utilize assisted reproductive technology to become pregnant without any detriment to their cancer outcome, according to study…
David J. Adelstein, MD, FACP Meeting News Coverage

Top Takeaways from ASCO: Neck dissection in head and neck cancer

August 3, 2015
CHICAGO – The decision-making process used by physicians to determine whether a neck dissection is appropriate in patients with head and neck cancer may change as…
In the Journals

Most nonmelanoma skin cancers treated with other modalities found appropriate for Mohs surgery

August 3, 2015
Most nonmelanoma skin cancer cases treated with Mohs microscopic surgery during a 3-month period met appropriate use criteria, while other cases that met criteria for…
In the Journals

Precancerous lesions increase risk for gastric cancer in low-risk population

August 3, 2015
A population-based cohort study in Sweden demonstrated patients with gastric precancerous lesions at all stages of progression based on Correa’s cascade increased…
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CME
Hematology Oncology Case Consults

The Patient with Multiple Myeloma

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with multiple myeloma.
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Meeting News Coverage Video
VIDEO: 'Care paths' may help manage rising cancer costs

VIDEO: 'Care paths' may help manage rising cancer costs

June 19, 2015
CHICAGO — Brian Bolwell, MD, chairman of Taussig Cancer Institute at Cleveland Clinic, discusses an abstract on…
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CME
Hematology Oncology Case Consults

Diagnosis and Management of Hemophilia

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of the patient with hemophilia supplemented with a case…
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