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Oophorectomy may decrease BRCA1-mutated breast cancer mortality

Oophorectomy may decrease BRCA1-mutated breast cancer mortality
May 22, 2015

Women with ER-negative breast cancer who harbor BRCA1 mutations may experience a survival benefit from undergoing oophorectomy, according to the results of a retrospective analysis.

 “Women who carry a germline mutation in either the BRCA1 or BRCA2 gene face a lifetime risk of breast cancer of up to 70%, and once they receive a diagnosis of breast cancer, they face high risks of both second primary breast and ovarian cancer,” Steven A. Narod, MD, of the Women’s College Research Institute, and colleagues wrote. “Preventive salpingo-oophorectomy  is recommended to women with a BRCA mutation at age 35 years or thereafter to prevent breast and ovarian cancer, but the benefit of oophorectomy may extend to reducing mortality from breast cancer as well.”

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