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Personalized vaccines provoke antitumor activity in melanoma

Personalized vaccines provoke antitumor activity in melanoma
May 27, 2015

A dendritic cell vaccine targeted at patient-specific neoantigens expanded the antitumor immune response in patients with melanoma, according to study results.

“Neoantigens are like flags on a cancer cell, calling attention to the immune system,” Beatriz M. Carreno, PhD, of the division of oncology at Washington University School of Medicine, said during a press conference. “In any one patient with melanoma, there can be hundreds of flags on tumors. The challenge presented to us was how to identify the unique flags that were more likely to elicit a strong immune response against the tumor.”

In the Journals

Past breast-feeding may decrease risk for breast cancer recurrence, death

May 27, 2015
Previous breast-feeding was linked to reduced risks for disease recurrence and breast-cancer death in women with breast cancer, according to study results.Women who…
In the Journals

Treatment type, location influence survival outcomes for oral cavity cancer

May 26, 2015
Early stage oral cavity squamous cell cancer outcomes tended to vary according to patient demographics, tumor characteristics and treatment factors, according to the…
Maria E. Cabanillas, MD, FACE In the Journals

Lenvatinib shows promise for radioiodine-refractory, differentiated thyroid cancer

May 26, 2015
Patients with advanced, radioiodine-refractory, differentiated thyroid cancer demonstrated encouraging response rates and PFS when treated with lenvatinib, according to…
Meeting News Coverage

Mutational load predicts progression in patients with Barrett's esophagus

May 26, 2015
Genetic mutations at several key loci predicted whether patients with Barrett’s esophagus who had no dysplasia or low-grade dysplasia at baseline would progress to…
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CME CNE
Low Risk AAMDS

Treatment Decision-Making through the Spectrum of MDS:
Case 1 Low Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain MDS…
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Meeting News Coverage Video
VIDEO: Updates in prostate cancer treatment options

VIDEO: Updates in prostate cancer treatment options

May 5, 2015
Robert S. DiPaola, MD, director of Rutgers Cancer Institute of New Jersey, discusses various forms of prostate cancer…
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CME
Hematology Oncology Case Consults

The Patient with Melanoma

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with melanoma.
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