Sarcoma

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FDA grants accelerated approval to Keytruda for solid tumors with specific biomarker

May 23, 2017

The FDA today granted accelerated approval to pembrolizumab for adults and children with unresectable or metastatic, microsatellite instability–high or mismatch repair–deficient solid tumors.

This indication for pembrolizumab (Keytruda, Merck) — the FDA’s first tissue/site-agnostic approval — includes patients with solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options, as well as patients with colorectal cancer that has progressed following treatment with fluoropyrimidine, oxaliplatin and irinotecan.

In the Journals Plus

Younger age linked to poorer survival from second cancers

May 22, 2017
Younger age at the time of a second primary malignant neoplasm diagnosis appeared linked to worse survival outcomes among cancer survivors, according to a retrospective…
In the Journals Plus

Rare cancers represent 20% of US cancer diagnoses

May 19, 2017
Rare malignancies accounted for about one in five cancer diagnoses in the United States from 2009 to 2013, according to an American Cancer Society report published in…
FDA News

FDA grants breakthrough therapy designation to entrectinib for NTRK fusion–positive solid tumors

May 15, 2017
The FDA granted breakthrough therapy designation to entrectinib for the treatment of NTRK fusion–positive locally advanced or metastatic solid tumors, according to…
CME

Toward Precision Medicine for Advanced Melanoma Management: Making the Most of Targeted Agents

This activity is supported by an educational grant from Novartis.

The identification and utilization of melanoma specific biomarkers continues to be of importance for diagnosis and…
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Video
Meeting News Coverage

VIDEO: Developing targeted therapy for sarcoma remains a challenge

June 13, 2016
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ASCO Annual Meeting

ASCO Annual Meeting

CNE CME

The Identification and Management of Immune-related Adverse Events in Patients with Cancer: Practice Essentials for Emergency Medicine Providers

This activity is supported by an educational grant from Bristol-Myers Squibb.

The incorporation of immunotherapies, especially the immune checkpoint inhibitors, into treatment regimens for patients…
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FDA News

FDA grants accelerated approval to Keytruda for solid tumors with specific biomarker

May 23, 2017
The FDA today granted accelerated approval to pembrolizumab for adults and children with unresectable or metastatic, microsatellite…

In the Journals Plus

Younger age linked to poorer survival from second cancers

May 22, 2017
Younger age at the time of a second primary malignant neoplasm diagnosis appeared linked to worse survival outcomes among cancer survivors, according…

In the Journals Plus

Rare cancers represent 20% of US cancer diagnoses

May 19, 2017
Rare malignancies accounted for about one in five cancer diagnoses in the United States from 2009 to 2013, according to an American Cancer Society…

FDA News

FDA grants breakthrough therapy designation to entrectinib for NTRK fusion–positive solid tumors

May 15, 2017
The FDA granted breakthrough therapy designation to entrectinib for the treatment of NTRK fusion–positive locally advanced or metastatic solid…

FDA News

FDA grants orphan drug designation to larotrectinib for solid tumors with NTRK gene fusions

May 12, 2017
The FDA granted orphan drug designation to larotrectinib for the treatment of solid tumors with neurotrophic tyrosine receptor kinase–fusion…

Loyola Medicine radiation oncologist receives distinguished service award

May 6, 2017
Edward Melian, MD, a radiation oncologist with Loyola Medicine, received the Chicago Radiological Society’s Distinguished Service Award. The…

In the Journals Plus

First live births less common among cancer survivors

May 1, 2017
Survivors of childhood and adolescent cancer were less likely as adults to have a first live birth than adults who never had cancer, according to…

Memorial Sloan Kettering Cancer Center names head of solid tumor oncology

April 26, 2017
Luis A. Diaz, MD, has been named head of the division of solid tumor oncology in the department of medicine at Memorial Sloan Kettering Cancer…

FDA News

FDA issues warnings about fraudulent cancer treatments

April 25, 2017
The FDA issued warning letters to 14 U.S. companies that the agency contends are selling products fraudulently claimed to prevent, diagnose, treat or…

Penn professor to become American Academy of Orthopaedic Surgeons’ first female president

April 25, 2017
Kristy L. Weber, MD, will become the first female president of the American Academy of Orthopedic Surgeons in 2019. Weber, chief of orthopedic…

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