Top Story

Long-term treatment with trabectedin extends PFS, OS in soft tissue sarcoma

March 13, 2015

Patients with soft tissue sarcoma who received trabectedin until disease progression demonstrated significantly improved PFS and OS compared with patients who only received six cycles of treatment, according to study results.

“This retrospective analysis consistently confirms that trabectedin is an effective treatment for patients with advanced sarcoma of multiple histologies following relapse or disease progression after standard-of-care front-line chemotherapy,” Axel Le Cesne, MD, of the department of medicine at the Institut Gustave Roussy in Villejuif, France, and colleagues of the French Sarcoma Group wrote.

In the Journals

Targeted preoperative radiation reduces late toxicities in extremity sarcoma

March 4, 2015
The use of preoperative image-guided radiation therapy was associated with a reduction in late toxicities among patients with extremity soft tissue sarcoma, according to…
thumbnail for video 4083320513001 Meeting News CoverageVideo

Video: Highlights in cancer and HIV treatments at CROI 2015

February 27, 2015
Infectious Disease News Chief Medical Editor Paul Volberding, MD, reviews HIV and cancer treatment data presented here at CROI 2015. Highlights include cervical cancer…
In the Journals

Boosted PIs lower Kaposi sarcoma incidence

February 10, 2015
Recent data suggest longer duration of treatment with protease inhibitors boosted with Norvir was associated with a reduced incidence of Kaposi sarcoma among veterans…
CME
Activity cover

Targeted Therapy and Immunotherapy in the Management of Metastatic Melanoma: 2014 Updates

This activity is supported by an educational grant from Merck & Co., Inc.

Melanoma remains a challenging condition for clinicians. An array of targeted therapies and immunotherapy are in…
More »
CME
Hot melanoma

Targeted Therapy and Immunotherapy in the Management of Metastatic Melanoma: 2014 Updates - Monograph

Melanoma remains a challenging condition for clinicians. An array of targeted therapies and immunotherapy are in…
More »
In the Journals

Long-term treatment with trabectedin extends PFS, OS in soft tissue sarcoma

March 13, 2015
Patients with soft tissue sarcoma who received trabectedin until disease progression demonstrated significantly improved PFS and OS compared with…
In the Journals

Targeted preoperative radiation reduces late toxicities in extremity sarcoma

March 4, 2015
The use of preoperative image-guided radiation therapy was associated with a reduction in late toxicities among patients with extremity soft tissue…
thumbnail for video 4083320513001 Meeting News CoverageVideo

Video: Highlights in cancer and HIV treatments at CROI 2015

February 27, 2015
Infectious Disease News Chief Medical Editor Paul Volberding, MD, reviews HIV and cancer treatment data presented here at CROI 2015. Highlights…
In the Journals

Boosted PIs lower Kaposi sarcoma incidence

February 10, 2015
Recent data suggest longer duration of treatment with protease inhibitors boosted with Norvir was associated with a reduced incidence of Kaposi…
Maintaining public awareness is critical to solving the problem of drug shortages, according to J. Leonard Lichtenfeld, MD, MACP, deputy chief medical officer for the American Cancer Society. “If we don’t constantly revisit this and make people aware of it, then this will become the status quo,” he said. Cover StoryPublication Exclusive

Expectation of drug shortages has become ‘new norm’ for cancer care

HemOnc Today, February 10, 2015
More than 230 drugs appeared on the American Society of Health-System Pharmacists’ drug shortage list as of mid-January.The list — primarily…
FDA NewsDrug Pipeline

FDA grants priority review to Yondelis for treatment of advanced soft tissue sarcoma

February 3, 2015
The FDA has granted priority review to Yondelis for the treatment of patients with advanced soft tissue liposarcoma and leiomyosarcoma who have…
In the Journals

IG-IMRT showed favorable outcomes in skull base chordoma, chondrosarcoma

January 19, 2015
Patients with chordomas or chondrosarcomas of the skull base had favorable 5-year OS and local control after high-dose image-guided…
Meeting News Coverage

Preoperative transcutaneous oximetry predicted complications in sarcoma radiation

November 21, 2014
The use of preoperative transcutaneous oximetry may be useful in predicting wound-healing complications in patients undergoing surgery for soft…
FDA News

FDA grants fast track designation to TH-302 for metastatic soft tissue sarcoma

November 11, 2014
The FDA granted fast track designation to TH-302 as a potential treatment for previously untreated patients with metastatic or locally advanced…
In the Journals

Shorter therapy did not compromise outcomes in low-risk embryonal rhabdomyosarcoma

October 30, 2014
Shorter-duration therapy with vincristine, dactinomycin and lower-dose cyclophosphamide with radiation therapy did not compromise failure-free…
More Headlines »
morganatic-roan