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Bone mineral density score disparity highlights need to redefine osteoporosis in children

September 15, 2014

Defining pediatric osteoporosis based on lumbar spine-bone mineral density z score may be problematic due to differences in reference databases and variability in prevalent vertebral fracture association and prediction performance across databases, according to a presentation at the American Society for Bone and Mineral Research 2014 Annual Meeting.

“There is marked disparity among bone mineral density z scores generated by different reference databases,” Leanne Marie Ward, MD, FRCP, FAAP, of the University of Ottawa, Canada, told Endocrine Today. “This fact alone makes the use of a lumbar spine-bone mineral density (LS-BMD) threshold to define osteoporosis challenging in children.”

In the Journals

Obesity, reduced gonadal function linked in men surviving childhood cancer

August 19, 2014
In boys who have survived cancer, obesity was linked with gonadal dysfunction independent of the effects of treatments previously undergone for the disease, according to…
figure In the Journals

Noninvasive tool identified high coronary artery disease burden in childhood cancer survivors

August 8, 2014
Coronary CT angiography identified coronary artery disease in a high percentage of adult survivors of childhood Hodgkin’s lymphoma, according to study…
In the Journals

MRD-directed therapy improved outcomes in pediatric BCR-ABL1–like ALL

August 4, 2014
Pediatric patients with BCR-ABL1–like acute lymphoblastic leukemia who received risk-directed therapy based on minimal residual disease levels during remission…
CME
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New Advances, New Options: Evaluating the Changing Landscape of Hemophilia to Optimize Patient Outcomes

This activity is supported by an educational grant from Biogen Idec.

The bleeding abnormalities associated with hemophilia can have devastating consequences for patients. Recent advances…
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CME CNE
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Treatment Decision-Making through the Spectrum of MDS: Case 1 Low Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain MDS…
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Bone mineral density score disparity highlights need to redefine osteoporosis in children

September 15, 2014
Defining pediatric osteoporosis based on lumbar spine-bone mineral density z score may be problematic due to differences in reference databases and…
In the Journals

Obesity, reduced gonadal function linked in men surviving childhood cancer

August 19, 2014
In boys who have survived cancer, obesity was linked with gonadal dysfunction independent of the effects of treatments previously undergone for the…
figure In the Journals

Noninvasive tool identified high coronary artery disease burden in childhood cancer survivors

August 8, 2014
Coronary CT angiography identified coronary artery disease in a high percentage of adult survivors of childhood Hodgkin’s lymphoma, according…
In the Journals

MRD-directed therapy improved outcomes in pediatric BCR-ABL1–like ALL

August 4, 2014
Pediatric patients with BCR-ABL1–like acute lymphoblastic leukemia who received risk-directed therapy based on minimal residual disease levels…
In the Journals

Antifungal therapy may alter epidemiology of invasive mold infections

August 1, 2014
Treatment with antifungal therapy may be a risk factor for invasive mold infections, according to study findings in The Journal of the Pediatric
Institution Notes

St. Jude announces CEO appointment

HemOnc Today, August 10, 2014
James R. Downing, MD, took over as CEO of St. Jude Children’s Research Hospital in mid-July.
In the Journals

AAP updates standards for pediatric cancer centers

July 29, 2014
The AAP’s Section on Hematology/Oncology Executive Committee released updated standards for pediatric cancer centers, according to a policy…
In the Journals

Childhood cancer survivors lowered metabolic syndrome risk through lifestyle choices

July 28, 2014
Heart-healthy lifestyle choices were associated with a lower risk for metabolic syndrome among childhood cancer survivors, according to recent…
Institution Notes

Pediatric hematology/oncology society recognizes CHOP physician

July 17, 2014
Beverly J. Lange, MD, a physician and researcher at The Children’s Hospital of Philadelphia for more than 40 years, received the 2014…
Institution Notes

St. Jude researcher receives ASCO award

July 16, 2014
Leslie L. Robison, PhD, chair of the department of epidemiology at St. Jude Children’s Research Hospital, received the 2014 Pediatric Oncology…
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